Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.55 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.53 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.53 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.53 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.49 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2162974 | 0.80 | LMNA (0.63) | ROCK2HRH3PDK1PDK2PDK3 | |
| SCHEMBL20905153 | 0.80 | PDK1 (0.56) | ROCK2HRH3PDK1PDK2PDK3 | |
| SCHEMBL8803891 | 0.80 | PDK1 (0.56) | ROCK2HRH3PDK1PDK2PDK3 | |
| SCHEMBL28757282 | 0.78 | HRH3 (0.63) | HRH3PDK1PDK2PDK3PDK4 | |
| SCHEMBL8141384 | 0.78 | HRH3 (0.59) | ROCK2HRH3PDK1PDK2PDK3 | |
| SCHEMBL3905087 | 0.78 | PDK1 (0.54) | ROCK2HRH3PDK1PDK2PDK3 | |
| SCHEMBL30102438 | 0.78 | PDK1 (0.54) | ROCK2HRH3PDK1PDK2PDK3 | |
| SCHEMBL28499625 | 0.78 | HRH3 (0.70) | HRH3PDK1PDK2PDK3PDK4 | |
| SCHEMBL23113118 | 0.77 | PDK1 (0.56) | ROCK2HRH3PDK1PDK2PDK3 | |
| SCHEMBL22432716 | 0.76 | HRH3 (0.60) | HRH3PDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150246938-A1 | NOVEL OLEFIN DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2015-09-03 | — | — | US | disclosed |
| US-20150246938-A1 | NOVEL OLEFIN DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2015-09-03 | — | — | US | disclosed |
| US-7985763-B2 | using an thiourea compound or carbonyl thiourea compound; therapy for drug resistant infections | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2011-07-26 | — | — | US | disclosed |
| US-7985763-B2 | using an thiourea compound or carbonyl thiourea compound; therapy for drug resistant infections | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2011-07-26 | — | — | US | disclosed |
| US-7985763-B2 | using an thiourea compound or carbonyl thiourea compound; therapy for drug resistant infections | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2011-07-26 | — | — | US | disclosed |
| WO-2008124300-A1 | HEPATITIS C VIRUS INHIBITORS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2008-10-16 | — | — | WO | disclosed |
| WO-2008124300-A1 | HEPATITIS C VIRUS INHIBITORS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2008-10-16 | — | — | WO | disclosed |
| US-20080255189-A1 | HEPATITIS C VIRUS INHIBITORS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2008-10-16 | — | — | US | disclosed |
| US-20080255189-A1 | HEPATITIS C VIRUS INHIBITORS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2008-10-16 | — | — | US | disclosed |
| US-20080255189-A1 | HEPATITIS C VIRUS INHIBITORS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246938-A1 | NOVEL OLEFIN DERIVATIVE | ACSS2, ACACB, ACAT2 | ROCK2 229/4885HRH3 289/4885PDK1 1055/4885 |
| US-20080255189-A1 | HEPATITIS C VIRUS INHIBITORS | HAVCR2, ZC3HAV1, ZC3HAV1L | ROCK2 2891/4885HRH3 1469/4885PDK1 3447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.