Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.30 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.30 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4387071 | 0.87 | MEN1 (0.33) | MEN1KMT2AHTTSMN1; SMN2KDM4E | |
| SCHEMBL5405785 | 0.79 | TOP2A (0.31) | MEN1KMT2AHTTKDM4EALDH1A1 | |
| SCHEMBL15468284 | 0.73 | HTT (0.31) | HTTSMN1; SMN2KDM4E | |
| SCHEMBL13202049 | 0.70 | MEN1 (0.33) | MEN1KMT2AHTTKDM4E | |
| SCHEMBL13202053 | 0.70 | MEN1 (0.33) | MEN1KMT2AHTTKDM4E | |
| SCHEMBL7634030 | 0.67 | MAOB (0.35) | MAOB | |
| SCHEMBL1150230 | 0.67 | ALDH1A1 (0.31) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL16623951 | 0.67 | TSHR (0.39) | MEN1KMT2AHTTKDM4EPOLB | |
| SCHEMBL16623950 | 0.67 | TSHR (0.39) | MEN1KMT2AHTTKDM4EPOLB | |
| SCHEMBL25184322 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7985594-B2 | Biradical polarizing agents for dynamic nuclear polarization | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2011-07-26 | — | — | US | claimed |
| US-20090311189-A1 | TEMPERATURE-JUMP DYNAMIC NUCLEAR POLARIZATION | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-12-17 | — | — | US | claimed |
| US-20090302842-A1 | BIRADICAL POLARIZING AGENTS FOR DYNAMIC NUCLEAR POLARIZATION | MASSACHUSETTS INSTITUTE OF TECNOLOGY (US) | 2009-12-10 | — | — | US | claimed |
| EP-2018545-A2 | BIRADICAL POLARIZING AGENTS FOR DYNAMIC NUCLEAR POLARIZATION | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-01-28 | — | — | EP | claimed |
| WO-2008048714-A2 | BIRADICAL POLARIZING AGENTS FOR DYNAMIC NUCLEAR POLARIZATION | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2008-04-24 | — | — | WO | claimed |
| WO-2007134160-A2 | TEMPERATURE-JUMP DYNAMIC NUCLEAR POLARIZATION | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2007-11-22 | — | — | WO | claimed |
| US-9035054-B2 | Dinitroxide-type biradical compounds optimized for dynamic nuclear polarization (DNP) | UNIVERSITE D'AIX-MARSEILLE (FR) | 2015-05-19 | — | — | US | disclosed |
| US-20140231775-A1 | DENDRIMER COMPOUND AND ORGANIC LUMINESCENT DEVICE EMPLOYING THE SAME | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2014-08-21 | — | — | US | disclosed |
| US-20140186969-A1 | DINITROXIDE-TYPE BIRADICAL COMPOUNDS OPTIMIZED FOR DYNAMIC NUCLEAR POLARIZATION (DNP) | UNIVERSITE D'AIX-MARSEILLE (FR) | 2014-07-03 | — | — | US | disclosed |
| US-8648193-B2 | Dinitroxide-type biradical compounds optimized for dynamic nuclear polarization (DNP) | UNIVERSITE D'AIX MARSEILLE (FR) | 2014-02-11 | — | — | US | disclosed |
| EP-2411390-B1 | DINITROXIDE BIRADICAL COMPOUNDS OPTIMIZED FOR DYNAMIC NUCLEAR POLARIZATION (DNP) | UNIV AIX MARSEILLE (FR) | 2014-01-29 | — | — | EP | disclosed |
| US-20130335079-A1 | NUCLEAR MAGNETIC RESONANCE PROBE HEAD AND METHOD WITH MULTI-FUNCTIONAL SAMPLE ROTATION | SAMOSON AGO (EE) | 2013-12-19 | — | — | US | disclosed |
| US-7985594-B2 | Biradical polarizing agents for dynamic nuclear polarization | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2011-07-26 | — | — | US | disclosed |
| US-20100249386-A1 | DINITROXIDE-TYPE BIRADICAL COMPOUNDS OPTIMIZED FOR DYNAMIC NUCLEAR POLARIZATION (DNP) | UNIVERSITE DE PROVENCE (FR) | 2010-09-30 | — | — | US | disclosed |
| US-20090311189-A1 | TEMPERATURE-JUMP DYNAMIC NUCLEAR POLARIZATION | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-12-17 | — | — | US | disclosed |
| US-20090302842-A1 | BIRADICAL POLARIZING AGENTS FOR DYNAMIC NUCLEAR POLARIZATION | MASSACHUSETTS INSTITUTE OF TECNOLOGY (US) | 2009-12-10 | — | — | US | disclosed |
| EP-2018545-A2 | BIRADICAL POLARIZING AGENTS FOR DYNAMIC NUCLEAR POLARIZATION | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-01-28 | — | — | EP | disclosed |
| WO-2008048714-A2 | BIRADICAL POLARIZING AGENTS FOR DYNAMIC NUCLEAR POLARIZATION | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2008-04-24 | — | — | WO | disclosed |
| WO-2007134160-A2 | TEMPERATURE-JUMP DYNAMIC NUCLEAR POLARIZATION | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2007-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090302842-A1 | BIRADICAL POLARIZING AGENTS FOR DYNAMIC NUCLEAR POLARIZATION | NUMA1, KPNA2, MEN1 | MEN1 3/4885KMT2A 2365/4885HTT 2911/4885 |
| US-20100249386-A1 | DINITROXIDE-TYPE BIRADICAL COMPOUNDS OPTIMIZED FOR DYNAMIC NUCLEAR POLARIZATION (DNP) | NME4, NDC1, MT-ND4L | MEN1 982/4885KMT2A 2309/4885HTT 1938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.