Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.30 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.30 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2163885 | 0.87 | MEN1 (0.33) | MEN1KMT2AHTTSMN1; SMN2KDM4E | |
| SCHEMBL15468284 | 0.86 | HTT (0.31) | HTTSMN1; SMN2KDM4E | |
| SCHEMBL26290593 | 0.84 | GAA (0.36) | MEN1KMT2AHTTSMN1; SMN2KDM4E | |
| SCHEMBL13202049 | 0.82 | MEN1 (0.33) | MEN1KMT2AHTTKDM4E | |
| SCHEMBL2025232 | 0.80 | GAA (0.33) | MEN1KMT2AHTTGAAL3MBTL1 | |
| SCHEMBL987956 | 0.78 | MEN1 (0.33) | MEN1KMT2AHTTGAAL3MBTL1 | |
| SCHEMBL5405789 | 0.78 | KDM4E (0.32) | MEN1KMT2AHTTKDM4E | |
| SCHEMBL12468548 | 0.77 | GAA (0.32) | MEN1KMT2AHTTGAAL3MBTL1 | |
| SCHEMBL7211170 | 0.77 | MEN1 (0.30) | MEN1KMT2AHTT | |
| SCHEMBL16623950 | 0.76 | TSHR (0.39) | MEN1KMT2AHTTKDM4EADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230040736-A1 | DINITROXIDE BIRADICAL COMPOUNDS AS POLARIZING AGENTS | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2023-02-09 | — | — | US | disclosed |
| US-11472790-B2 | Dinitroxide biradical compounds as polarizing agents | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2022-10-18 | — | — | US | disclosed |
| US-20200148666-A1 | DINITROXIDE BIRADICAL COMPOUNDS AS POLARIZING AGENTS | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2020-05-14 | — | — | US | disclosed |
| WO-2019007989-A9 | DINITROXIDE BIRADICAL COMPOUNDS AS POLARIZING AGENTS | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2019-12-26 | — | — | WO | disclosed |
| US-10414729-B2 | Site-specific dynamic nuclear polarization NMR agents | NORTH CAROLINA STATE UNIVERSITY (US) | 2019-09-17 | — | — | US | disclosed |
| WO-2019007989-A1 | DINITROXIDE BIRADICAL COMPOUNDS AS POLARIZING AGENTS | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2019-01-10 | — | — | WO | disclosed |
| EP-3424921-A1 | DINITROXIDE BIRADICAL COMPOUNDS AS POLARIZING AGENTS | Commissariat à l'Energie Atomique et aux Energies Alternatives (FR) | 2019-01-09 | — | — | EP | disclosed |
| US-20170029377-A1 | SITE-SPECIFIC DYNAMIC NUCLEAR POLARIZATION NMR AGENTS | UNITED STATES DEPARTMENT OF ENERGY | 2017-02-02 | — | — | US | disclosed |
| US-20170029377-A1 | SITE-SPECIFIC DYNAMIC NUCLEAR POLARIZATION NMR AGENTS | UNITED STATES DEPARTMENT OF ENERGY | 2017-02-02 | — | — | US | disclosed |
| US-20160195480-A1 | NON AQUEOUS SOLVENTS OR MIXTURES FOR DNP NMR SPECTROSCOPY, METHOD TO PREPARE SAID SOLVENTS OR MIXTURES AND USE OF SAID SOLVENTS OR MIXTURES | BRUKER BIOSPIN (FR) | 2016-07-07 | — | — | US | disclosed |
| US-7985594-B2 | Biradical polarizing agents for dynamic nuclear polarization | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2011-07-26 | — | — | US | disclosed |
| US-20090302842-A1 | BIRADICAL POLARIZING AGENTS FOR DYNAMIC NUCLEAR POLARIZATION | MASSACHUSETTS INSTITUTE OF TECNOLOGY (US) | 2009-12-10 | — | — | US | disclosed |
| US-20090302842-A1 | BIRADICAL POLARIZING AGENTS FOR DYNAMIC NUCLEAR POLARIZATION | MASSACHUSETTS INSTITUTE OF TECNOLOGY (US) | 2009-12-10 | — | — | US | disclosed |
| EP-2018545-A2 | BIRADICAL POLARIZING AGENTS FOR DYNAMIC NUCLEAR POLARIZATION | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-01-28 | — | — | EP | disclosed |
| WO-2008048714-A2 | BIRADICAL POLARIZING AGENTS FOR DYNAMIC NUCLEAR POLARIZATION | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2008-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090302842-A1 | BIRADICAL POLARIZING AGENTS FOR DYNAMIC NUCLEAR POLARIZATION | NUMA1, KPNA2, MEN1 | MEN1 3/4885KMT2A 2365/4885HTT 2911/4885 |
| US-11472790-B2 | Dinitroxide biradical compounds as polarizing agents | NDC1, NUCB2, MDM4 | MEN1 473/4885KMT2A 4409/4885HTT 2506/4885 |
| US-20200148666-A1 | DINITROXIDE BIRADICAL COMPOUNDS AS POLARIZING AGENTS | NDC1, NUCB2, MDM4 | MEN1 473/4885KMT2A 4409/4885HTT 2506/4885 |
| US-20170029377-A1 | SITE-SPECIFIC DYNAMIC NUCLEAR POLARIZATION NMR AGENTS | ADAR, HNRNPR, ANP32A | MEN1 3872/4885KMT2A 3312/4885HTT 1689/4885 |
| US-10414729-B2 | Site-specific dynamic nuclear polarization NMR agents | ADAR, HNRNPR, ANP32A | MEN1 3872/4885KMT2A 3312/4885HTT 1689/4885 |
| US-20230040736-A1 | DINITROXIDE BIRADICAL COMPOUNDS AS POLARIZING AGENTS | NDC1, NUCB2, MDM4 | MEN1 473/4885KMT2A 4409/4885HTT 2506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.