Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.66 |
| ▸ | RAB9A | P51151 | 7/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.54 |
| ▸ | ALPL | P05186 | 1/20 | 0.53 |
| ▸ | ALPG | P10696 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21643773 | 0.85 | DRD2 (0.72) | NPC1RAB9ASMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL21643747 | 0.84 | TSHR (0.55) | NPC1RAB9AHDAC6HDAC1DRD2 | |
| SCHEMBL21643752 | 0.83 | HDAC6 (0.57) | NPC1RAB9ASMN1; SMN2KMT2AHDAC6 | |
| SCHEMBL21660948 | 0.83 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2KMT2AHDAC6 | |
| SCHEMBL4980057 | 0.83 | HDAC1 (0.62) | NPC1RAB9ASMN1; SMN2KMT2AHDAC6 | |
| SCHEMBL21660946 | 0.82 | ALDH1A1 (0.58) | NPC1RAB9ASMN1; SMN2KMT2AHDAC6 | |
| SCHEMBL2727856 | 0.81 | HDAC6 (0.73) | NPC1RAB9AHDAC6HDAC1 | |
| SCHEMBL4983837 | 0.79 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2KMT2AHDAC1 | |
| SCHEMBL20715541 | 0.78 | RAB9A (0.77) | NPC1RAB9ASMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL5944072 | 0.76 | HDAC1 (0.73) | NPC1RAB9ASMN1; SMN2KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10934255-B2 | Nrf and HIF activators/HDAC inhibitors and therapeutic methods using the same | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2021-03-02 | — | — | US | disclosed |
| US-10934255-B2 | Nrf and HIF activators/HDAC inhibitors and therapeutic methods using the same | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2021-03-02 | — | — | US | disclosed |
| US-20200039933-A1 | NRF AND HIF ACTIVATORS/HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2020-02-06 | — | — | US | disclosed |
| US-20200039933-A1 | NRF AND HIF ACTIVATORS/HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2020-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934255-B2 | Nrf and HIF activators/HDAC inhibitors and therapeutic methods using the same | HIF1AN, KEAP1, NFE2L2 | NPC1 1029/4885RAB9A 2126/4885SMN1; SMN2 392/4885 |
| US-20200039933-A1 | NRF AND HIF ACTIVATORS/HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | HIF1AN, KEAP1, NFE2L2 | NPC1 1029/4885RAB9A 2126/4885SMN1; SMN2 392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.