Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 9/20 | 0.50 |
| ▸ | RORC | P51449 | 3/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.48 |
| ▸ | RORA | P35398 | 2/20 | 0.45 |
| ▸ | RORB | Q92753 | 2/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21647692 | 0.80 | SMN1; SMN2 (0.60) | SMN1; SMN2RORCALDH1A1MAPTMEN1 | |
| SCHEMBL1963814 | 0.78 | MEN1 (0.62) | ESR1SMN1; SMN2NR1I2RORCALDH1A1 | |
| SCHEMBL5731154 | 0.76 | RORC (0.57) | ESR1SMN1; SMN2NR1I2RORCNR1H2 | |
| SCHEMBL21647723 | 0.74 | SMN1; SMN2 (0.46) | ESR1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL16794196 | 0.72 | PTGER1 (0.54) | SMN1; SMN2RORCALDH1A1MEN1KMT2A | |
| SCHEMBL6624409 | 0.71 | ESR1 (0.52) | ESR1RORCALDH1A1KMT2ANPSR1 | |
| SCHEMBL21647773 | 0.71 | LMNA (0.60) | SMN1; SMN2ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL19065098 | 0.69 | HDAC8 (0.64) | SMN1; SMN2NR1I2RORCNR1H2RORA | |
| SCHEMBL4610072 | 0.69 | NR1H3 (0.53) | ESR1NR1I2NR1H2ALDH1A1NR1H3 | |
| SCHEMBL22441784 | 0.68 | LMNA (0.57) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250188023-A1 | BENZENE DERIVATIVE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2025-06-12 | — | — | US | disclosed |
| US-12258308-B2 | Benzene derivative | ONO PHARMACEUTICAL CO., LTD. (JP) | 2025-03-25 | — | — | US | disclosed |
| CN-112513011-B | Benzene derivatives | 小野药品工业株式会社 | 2023-06-16 | — | — | CN | disclosed |
| US-20220089532-A1 | BENZENE DERIVATIVE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2022-03-24 | — | — | US | disclosed |
| US-11261154-B2 | Benzene derivative | ONO PHARMACEUTICAL CO., LTD. (JP) | 2022-03-01 | — | — | US | disclosed |
| US-20210332009-A1 | BENZENE DERIVATIVE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2021-10-28 | — | — | US | disclosed |
| EP-3831810-A1 | BENZENE DERIVATIVE | ONO Pharmaceutical Co., Ltd. (JP) | 2021-06-09 | — | — | EP | disclosed |
| CN-112513011-A | Benzene derivatives | 小野药品工业株式会社 | 2021-03-16 | — | — | CN | disclosed |
| WO-2020027150-A1 | BENZENE DERIVATIVE | 小野薬品工業株式会社 | 2020-02-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12258308-B2 | Benzene derivative | PMP22, TMBIM6, MYT1 | ESR1 4559/4885SMN1; SMN2 44/4885NR1I2 1660/4885 |
| US-11261154-B2 | Benzene derivative | PMP22, TMBIM6, MYT1 | ESR1 4559/4885SMN1; SMN2 44/4885NR1I2 1660/4885 |
| US-20250188023-A1 | BENZENE DERIVATIVE | PMP22, TMBIM6, MYT1 | ESR1 4538/4885SMN1; SMN2 49/4885NR1I2 1686/4885 |
| US-20210332009-A1 | BENZENE DERIVATIVE | PMP22, TMBIM6, MYT1 | ESR1 4559/4885SMN1; SMN2 44/4885NR1I2 1660/4885 |
| US-20220089532-A1 | BENZENE DERIVATIVE | PMP22, TMBIM6, MYT1 | ESR1 4559/4885SMN1; SMN2 44/4885NR1I2 1660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.