SCHEMBL216485

SCHEMBL216485

CCN(CC)c1ccc(C(=NO[Si](C)(C)C)c2ccc(N(CC)CC)cc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.41
GAA P10253 3/20 0.41
KDM4E B2RXH2 3/20 0.41
MEN1 O00255 4/20 0.40
KMT2A Q03164 4/20 0.40
CYP3A4 P08684 2/20 0.40
TSHR P16473 2/20 0.40
PSMD14 O00487 1/20 0.40
MAPK1 P28482 1/20 0.40
RECQL P46063 1/20 0.40
GFER P55789 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
MAPT P10636 7/20 0.40
POLB P06746 2/20 0.40
MCL1 Q07820 1/20 0.40
NOX1 Q9Y5S8 1/20 0.40
HDAC6 Q9UBN7 2/20 0.39
HDAC3 O15379 1/20 0.39
HDAC4 P56524 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL215575 0.83 HSD11B1 (0.41) ALDH1A1GAAKDM4EMEN1KMT2A
SCHEMBL216089 0.81 MAPT (0.46) ALDH1A1GAAKDM4EMEN1KMT2A
SCHEMBL214936 0.79 CNR2 (0.45) ALDH1A1KDM4EMEN1KMT2ACYP3A4
SCHEMBL213048 0.77 ALDH1A1 (0.41) ALDH1A1GAAKDM4EMEN1KMT2A
SCHEMBL214657 0.75 MAPT (0.49) ALDH1A1GAAKDM4EMEN1KMT2A
SCHEMBL6025280 0.74 ALDH1A1 (0.53) ALDH1A1GAAKDM4EMEN1KMT2A
SCHEMBL14221026 0.74 MAPT (0.50) ALDH1A1GAAKDM4EMEN1KMT2A
SCHEMBL212399 0.73 ALDH1A1 (0.38) ALDH1A1GAAKDM4EMEN1KMT2A
SCHEMBL212674 0.72 ALDH1A1 (0.41) ALDH1A1MEN1KMT2ACYP3A4MAPK1
SCHEMBL214237 0.70 ALDH1A1 (0.57) ALDH1A1GAAKDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8088868-B2 oximation of cojugated homopolymers formed by addtion polymerization of conjugated diene monomer in the presence lanthanide copmpounds as polymerization catalysts; polymers used in the manufacture of tires having reduced hysteresis BRIDGESTONE CORPORATION (JP) 2012-01-03 US claimed
US-20080146745-A1 POLYMERS FUNCTIONALIZED WITH PROTECTED OXIME COMPOUNDS BRIDGESTONE CORPORATION (JP) 2008-06-19 US claimed
US-8088868-B2 oximation of cojugated homopolymers formed by addtion polymerization of conjugated diene monomer in the presence lanthanide copmpounds as polymerization catalysts; polymers used in the manufacture of tires having reduced hysteresis BRIDGESTONE CORPORATION (JP) 2012-01-03 US disclosed
US-20080146745-A1 POLYMERS FUNCTIONALIZED WITH PROTECTED OXIME COMPOUNDS BRIDGESTONE CORPORATION (JP) 2008-06-19 US disclosed