Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1L | O00429 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 2/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | POLQ | O75417 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14479883 | 0.81 | PTPN1 (0.60) | DNM1LRAB9ANPC1SMN1; SMN2PTPN11 | |
| SCHEMBL21653229 | 0.74 | RAB9A (0.42) | RAB9ANPC1SMN1; SMN2PTPN11ALDH1A1 | |
| SCHEMBL6246566 | 0.74 | PLA2G10 (0.59) | RAB9ANPC1CLK1SMN1; SMN2PLA2G10 | |
| SCHEMBL18573457 | 0.70 | PTPN1 (0.63) | RAB9ANPC1SMN1; SMN2PTPN11PTPN1 | |
| SCHEMBL21653250 | 0.66 | ALDH1A1 (0.43) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL21653105 | 0.66 | ALDH1A1 (0.41) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL21653109 | 0.66 | NPC1 (0.37) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL18573582 | 0.66 | PTPN1 (0.63) | RAB9ANPC1SMN1; SMN2PTPN11PTPN1 | |
| SCHEMBL12922744 | 0.66 | GAA (0.71) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL21653230 | 0.66 | ALDH1A1 (0.49) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |