Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21667303 | 0.88 | PDE9A (0.46) | PGRGPR84MAPTLMNATP53 | |
| SCHEMBL21667314 | 0.88 | CDK1 (0.44) | ALDH1A1GAAKDM4ECYP3A4MAPT | |
| SCHEMBL21667181 | 0.86 | PDE9A (0.48) | ALDH1A1MAPTTSHRDAO | |
| SCHEMBL21667176 | 0.80 | CYP3A4 (0.49) | PGRGPR84ALDH1A1HPGDGAA | |
| SCHEMBL22367979 | 0.78 | SMN1; SMN2 (0.46) | GPR84KDM4ECYP3A4MAPTLMNA | |
| SCHEMBL16322100 | 0.77 | CYP3A4 (0.46) | PGRCYP3A4HTT | |
| SCHEMBL30509657 | 0.77 | CYP3A4 (0.46) | PGRCYP3A4HTT | |
| SCHEMBL16322101 | 0.77 | CYP3A4 (0.46) | PGRCYP3A4HTT | |
| SCHEMBL21667336 | 0.76 | CDK1 (0.45) | ALDH1A1GAAKDM4ECYP3A4MAPT | |
| SCHEMBL21667316 | 0.73 | CDK1 (0.44) | ALDH1A1GAAKDM4ECYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |