Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | PDE9A | O76083 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21667336 | 0.88 | CDK1 (0.45) | CDK1PDE9APOLBMEN1MAPT | |
| SCHEMBL21667179 | 0.88 | PGR (0.44) | MAPTKDM4ECYP3A4ALDH1A1GAA | |
| SCHEMBL22367979 | 0.87 | SMN1; SMN2 (0.46) | CDK1POLBMEN1MAPTKMT2A | |
| SCHEMBL21667303 | 0.86 | PDE9A (0.46) | PDE9AMAPT | |
| SCHEMBL21667316 | 0.84 | CDK1 (0.44) | CDK1PDE9APOLBMEN1MAPT | |
| SCHEMBL21667181 | 0.84 | PDE9A (0.48) | CDK1PDE9AMEN1MAPTKMT2A | |
| SCHEMBL16321187 | 0.77 | CYP3A4 (0.56) | PDE9APOLBMEN1KMT2ACYP3A4 | |
| SCHEMBL16321188 | 0.77 | CYP3A4 (0.56) | PDE9APOLBMEN1KMT2ACYP3A4 | |
| SCHEMBL16322530 | 0.76 | CYP3A4 (0.43) | CDK1POLBKDM4ENPSR1CYP3A4 | |
| SCHEMBL16322533 | 0.76 | CYP3A4 (0.43) | CDK1POLBKDM4ENPSR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |