Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21667314 | 0.87 | CDK1 (0.44) | SMN1; SMN2L3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL21667179 | 0.78 | PGR (0.44) | LMNAHTTTP53GPR84MAPT | |
| SCHEMBL21667303 | 0.76 | PDE9A (0.46) | LMNATP53GPR84MAPTADORA1 | |
| SCHEMBL21667336 | 0.75 | CDK1 (0.45) | SMN1; SMN2L3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL16321187 | 0.75 | CYP3A4 (0.56) | SMN1; SMN2HTTL3MBTL1MEN1KMT2A | |
| SCHEMBL16321188 | 0.75 | CYP3A4 (0.56) | SMN1; SMN2HTTL3MBTL1MEN1KMT2A | |
| SCHEMBL21667181 | 0.75 | PDE9A (0.48) | TAAR1MEN1KMT2AMAPTTSHR | |
| SCHEMBL21667365 | 0.74 | SMN1; SMN2 (0.70) | SMN1; SMN2LMNAHTTTP53GPR84 | |
| SCHEMBL16322530 | 0.74 | CYP3A4 (0.43) | SMN1; SMN2HTTKDM4EBRD4POLB | |
| SCHEMBL18898509 | 0.72 | LMNA (0.40) | SMN1; SMN2LMNAHTTL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |