Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 2/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21667179 | 0.88 | PGR (0.44) | PGRLMNAMAPTGPR84TP53 | |
| SCHEMBL21667314 | 0.86 | CDK1 (0.44) | PDE9AMAPT | |
| SCHEMBL21667181 | 0.84 | PDE9A (0.48) | PDE9AMAPT | |
| SCHEMBL16321660 | 0.79 | CYP3A4 (0.48) | PGR | |
| SCHEMBL16321659 | 0.79 | CYP3A4 (0.48) | PGR | |
| SCHEMBL21667306 | 0.79 | CYP3A4 (0.50) | PDE9APGRFABP4LMNAMAPT | |
| SCHEMBL22367979 | 0.76 | SMN1; SMN2 (0.46) | LMNAMAPTGPR84ADORA1TP53 | |
| SCHEMBL21667336 | 0.74 | CDK1 (0.45) | PDE9AMAPT | |
| SCHEMBL21667316 | 0.71 | CDK1 (0.44) | PDE9ALMNAMAPT | |
| SCHEMBL21667176 | 0.71 | CYP3A4 (0.49) | PGRLMNAMAPTGPR84TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |