Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | GNRHR | P30968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21667179 | 0.86 | PGR (0.44) | MAPTALDH1A1TSHRDAO | |
| SCHEMBL21667303 | 0.84 | PDE9A (0.46) | PDE9AMAPT | |
| SCHEMBL21667314 | 0.84 | CDK1 (0.44) | PDE9AMEN1MAPTKMT2ACDK1 | |
| SCHEMBL21667252 | 0.79 | PDE9A (0.50) | PDE9AMEN1MAPTKMT2ACDK1 | |
| SCHEMBL22367979 | 0.75 | SMN1; SMN2 (0.46) | MEN1MAPTKMT2ACDK1TSHR | |
| SCHEMBL21667336 | 0.73 | CDK1 (0.45) | PDE9AMEN1MAPTKMT2ACDK1 | |
| SCHEMBL21667316 | 0.69 | CDK1 (0.44) | PDE9AMEN1MAPTKMT2ACDK1 | |
| SCHEMBL10056966 | 0.68 | P2RX3 (0.61) | MEN1MAPTKMT2AALDH1A1TSHR | |
| SCHEMBL16322100 | 0.67 | CYP3A4 (0.46) | — | |
| SCHEMBL21667176 | 0.67 | CYP3A4 (0.49) | MEN1MAPTKMT2AALDH1A1DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |