Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | CLPP | Q16740 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21667387 | 0.83 | PGR (0.47) | KMT2AMEN1POLBALDH1A1LMNA | |
| SCHEMBL21667215 | 0.82 | SMN1; SMN2 (0.53) | KMT2AMEN1GLAALDH1A1LMNA | |
| SCHEMBL21667281 | 0.79 | EGFR (0.53) | KMT2AMEN1MAPTDAOGAA | |
| SCHEMBL21667372 | 0.78 | ALDH1A1 (0.66) | KMT2AMEN1HSD17B10GLAPOLB | |
| SCHEMBL21667283 | 0.77 | KMT2A (0.50) | KMT2AMEN1HSD17B10GLAPOLB | |
| SCHEMBL13104661 | 0.76 | ALDH1A1 (0.47) | KMT2AMEN1HSD17B10GLAALDH1A1 | |
| SCHEMBL21667384 | 0.75 | GPR84 (0.45) | KMT2AMEN1HSD17B10GLAALDH1A1 | |
| SCHEMBL16322888 | 0.75 | SMN1; SMN2 (0.47) | KMT2AMEN1HSD17B10ALDH1A1LMNA | |
| SCHEMBL16322889 | 0.75 | SMN1; SMN2 (0.47) | KMT2AMEN1HSD17B10ALDH1A1LMNA | |
| SCHEMBL21667382 | 0.73 | ADORA1 (0.49) | KMT2AMEN1POLBSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |