Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.50 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | PKM | P14618 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.43 |
| ▸ | HBB | P68871 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9864517 | 0.81 | GSK3A (0.61) | MEN1KMT2AMAPTALDH1A1PKM | |
| SCHEMBL209877 | 0.80 | ALDH1A1 (0.72) | MEN1KMT2AMAPTALDH1A1PKM | |
| Potassium SCHEMBL11515942 | 0.79 | ALDH1A1 (0.70) | MEN1KMT2AMAPTALDH1A1PKM | |
| SCHEMBL77739 | 0.77 | KMT2A (0.73) | MEN1KMT2AMAPTALDH1A1PKM | |
| SCHEMBL18344445 | 0.75 | MAPT (0.57) | MEN1KMT2AMAPTALDH1A1PKM | |
| SCHEMBL5586057 | 0.75 | MAPT (0.57) | MEN1KMT2AMAPTALDH1A1PKM | |
| SCHEMBL1401654 | 0.74 | GSK3A (0.56) | MEN1KMT2AMAPTALDH1A1PKM | |
| SCHEMBL25035706 | 0.73 | PKM (0.56) | MEN1KMT2AMAPTALDH1A1PKM | |
| SCHEMBL14139251 | 0.73 | KMT2A (0.51) | MEN1KMT2AMAPTALDH1A1PKM | |
| SCHEMBL5014355 | 0.73 | MEN1 (0.51) | MEN1KMT2AMAPTALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |