SCHEMBL77739

SCHEMBL77739

O=C1CC(=O)N(Cc2ccccc2)C(=O)N1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 10/20 0.73
MEN1 O00255 9/20 0.73
MAPT P10636 7/20 0.65
ALDH1A1 P00352 5/20 0.65
GSK3A P49840 4/20 0.59
GSK3B P49841 4/20 0.59
HSD17B10 Q99714 3/20 0.58
POLB P06746 3/20 0.58
L3MBTL1 Q9Y468 3/20 0.58
RECQL P46063 2/20 0.58
PSMD14 O00487 1/20 0.58
MMP2 P08253 1/20 0.58
DNMT1 P26358 1/20 0.58
APEX1 P27695 1/20 0.58
PTPN7 P35236 1/20 0.58
HBB P68871 1/20 0.58
KDM4C Q9H3R0 1/20 0.58
TDP1 Q9NUW8 1/20 0.58
BLM P54132 2/20 0.53
USP2 O75604 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17717942 0.88 KMT2A (0.59) KMT2AMEN1MAPTALDH1A1GSK3A
SCHEMBL21359663 0.85 KMT2A (1.00) KMT2AMEN1MAPTALDH1A1GSK3A
SCHEMBL30998816 0.83 ALDH1A1 (0.72) KMT2AMEN1MAPTALDH1A1HSD17B10
SCHEMBL209877 0.83 ALDH1A1 (0.72) KMT2AMEN1MAPTALDH1A1GSK3A
SCHEMBL7734082 0.83 MEN1 (0.66) KMT2AMEN1MAPTALDH1A1GSK3A
SCHEMBL13729308 0.82 KMT2A (0.64) KMT2AMEN1MAPTALDH1A1GSK3A
Potassium SCHEMBL11515942 0.81 ALDH1A1 (0.70) KMT2AMEN1MAPTALDH1A1GSK3A
SCHEMBL1495220 0.81 MEN1 (0.52) KMT2AMEN1MAPTALDH1A1HSD17B10
SCHEMBL18835712 0.80 MEN1 (0.67) KMT2AMEN1MAPTALDH1A1GSK3A
SCHEMBL15419594 0.79 KMT2A (0.65) KMT2AMEN1MAPTALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1107 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118064087-A Precipitate-free single-component epoxy adhesive and preparation method and application thereof 深圳市汉思新材料科技有限公司 2024-05-24 CN claimed
WO-2021054927-A2 GLUTATHIONE-CHOLESTEROL DERIVATIVES AS BRAIN TARGETING AGENTS SOUTH DAKOTA BOARD OF REGENTS (US) 2021-03-25 WO claimed
US-20200048305-A1 GLUTATHIONE-CHOLESTEROL DERIVATIVES AS BRAIN TARGETING AGENTS SOUTH DAKOTA BOARD OF REGENTS (US) 2020-02-13 US claimed
US-9770514-B2 Tamper-resistant pharmaceutical dosage forms ExxPharma Therapeutics LLC (US) 2017-09-26 US claimed
US-9622969-B2 Polymer conjugated protein micelles SOUTH DAKOTA STATE UNIV (US) 2017-04-18 US claimed
US-20150064250-A1 Tamper-Resistant Pharmaceutical Dosage Forms ExxPharma Therapeutics LLC (US) 2015-03-05 US claimed
US-20140370110-A1 POLYMER CONJUGATED PROTEIN MICELLES SOUTH DAKOTA STATE UNIVERSITY (US) 2014-12-18 US claimed
CN-101415328-B Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same MASSACHUSETTS INST TECHNOLOGY 2014-03-05 CN claimed
CN-103599124-A Compositions containing CDP-choline, and methods of use thereof MASSACHUSETTS INST TECHNOLOGY 2014-02-26 CN claimed
EP-2560634-A1 NITRIC OXIDE RELEASING PRODRUGS OF THERAPEUTIC AGENTS Piramal Enterprises Limited (IN) 2013-02-27 EP claimed
US-20070043120-A1 Therapeutic combination for painful medical conditions UCB PHARMA GMBH (DE) 2007-02-22 US claimed
US-20070042969-A1 Combination therapy for pain in painful diabetic neuropathy SRZ PROPERTIES, INC. (US) 2007-02-22 US claimed
US-20060135551-A1 Novel heterocyclic compounds and their pharmaceutical compositions DR. REDDY'S LABORATORIES LTD. (IN) 2006-06-22 US claimed
JP-2003517437-A 2003-05-27 JP claimed
US-20020028787-A1 Nervous system disorders; administering exogenous uridine compound NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2002-03-07 US claimed
EP-1140104-A1 METHODS FOR INCREASING CYTIDINE LEVELS IN VIVO AND TREATING CYTIDINE-DEPENDENT HUMAN DISEASES Massachusetts Institute of Technology (US) 2001-10-10 EP claimed
CN-1294519-A Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient INPHARMA SA (CH) 2001-05-09 CN claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
US-3995021-A DIAZOTIZATION OF AN AMINO PHENYL SUBSTITUTED HAPTEN BIOLOGICAL DEVELOPMENTS, INC. (US) 1976-11-30 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070042969-A1 Combination therapy for pain in painful diabetic neuropathy GRIN2B, GRIN2A, GRIN3A KMT2A 617/4885MEN1 4370/4885MAPT 1158/4885
US-20200048305-A1 GLUTATHIONE-CHOLESTEROL DERIVATIVES AS BRAIN TARGETING AGENTS GSTK1, GSTO1, GSTM2 KMT2A 3630/4885MEN1 1607/4885MAPT 1050/4885
US-20140370110-A1 POLYMER CONJUGATED PROTEIN MICELLES MTDH, PSMG3, GHITM KMT2A 3102/4885MEN1 906/4885MAPT 651/4885
US-20070043120-A1 Therapeutic combination for painful medical conditions PDE1B, CA2, CACNA1S KMT2A 1606/4885MEN1 1264/4885MAPT 1343/4885
US-20060135551-A1 Novel heterocyclic compounds and their pharmaceutical compositions LIPC, PCSK9, PC KMT2A 3247/4885MEN1 1019/4885MAPT 2438/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.