SCHEMBL21670360

SCHEMBL21670360

O=C(Nc1ccc(Cl)c(F)c1)[C@H]1CCCOC1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.51
HDAC1 Q13547 1/20 0.51
HDAC2 Q92769 1/20 0.51
HPGD P15428 2/20 0.50
ALDH1A1 P00352 2/20 0.50
TSHR P16473 1/20 0.50
MGLL Q99685 1/20 0.49
EPHX2 P34913 2/20 0.47
MAOB P27338 1/20 0.46
KDM4E B2RXH2 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
MEN1 O00255 1/20 0.45
LMNA P02545 1/20 0.45
ALOX15 P16050 1/20 0.45
ALOX12 P18054 1/20 0.45
HTT P42858 1/20 0.45
KMT2A Q03164 1/20 0.45
EGLN2 Q96KS0 1/20 0.44
MALT1 Q9UDY8 1/20 0.44
MAPK10 P53779 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21670359 1.00 HDAC3 (0.51) HDAC3HDAC1HDAC2HPGDALDH1A1
SCHEMBL21669844 1.00 HDAC3 (0.51) HDAC3HDAC1HDAC2HPGDALDH1A1
SCHEMBL2241850 0.84 ALDH1A1 (0.60) HPGDALDH1A1TSHRMGLLKDM4E
SCHEMBL21669936 0.78 ULK1 (0.56) HPGDMGLLSMN1; SMN2MEN1LMNA
SCHEMBL21669919 0.78 ULK1 (0.56) HPGDMGLLSMN1; SMN2MEN1LMNA
SCHEMBL21670326 0.75 MGLL (0.52) HPGDMGLLSMN1; SMN2MEN1LMNA
SCHEMBL18707935 0.74 BACE1 (0.48) HDAC3HDAC1HDAC2EPHX2KDM4E
SCHEMBL21669772 0.72 RAB9A (0.53) ALDH1A1TSHRMGLLKDM4ESMN1; SMN2
SCHEMBL21669786 0.72 GAA (0.64) SMN1; SMN2MEN1LMNAHTTKMT2A
SCHEMBL16651163 0.72 PSMB8 (0.54) MGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020028482-A1 SMALL MOLECULES THAT SENSITIZE HIV-1 INFECTED CELLS TO ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2020-02-06 WO disclosed