Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CTSD | P07339 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL240024 | 0.86 | HSD17B10 (0.65) | SMN1; SMN2LMNAKMT2AHPGDALDH1A1 | |
| SCHEMBL28469776 | 0.85 | ABCG2 (0.61) | SMN1; SMN2ABCG2KMT2AALDH1A1MAPT | |
| SCHEMBL33469 | 0.85 | HCAR2 (0.50) | SMN1; SMN2HPGDALDH1A1MAPTHSD17B10 | |
| SCHEMBL21678701 | 0.84 | HCRTR1 (0.49) | LMNAKMT2AHPGDALDH1A1MAPT | |
| SCHEMBL21678779 | 0.84 | IRAK4 (0.53) | SMN1; SMN2LMNAHPGDALDH1A1MAPT | |
| Fumaric Acid SCHEMBL28398991 | 0.82 | HTT (0.66) | SMN1; SMN2LMNAABCG2KMT2AHPGD | |
| SCHEMBL21678752 | 0.81 | KMT2A (0.47) | SMN1; SMN2LMNAKMT2AHPGDALDH1A1 | |
| SCHEMBL446339 | 0.81 | HPGD (0.59) | SMN1; SMN2ABCG2KMT2AHPGDALDH1A1 | |
| SCHEMBL27385335 | 0.81 | HPGD (0.49) | SMN1; SMN2ABCG2KMT2AHPGDALDH1A1 | |
| SCHEMBL21678783 | 0.80 | LMNA (0.50) | SMN1; SMN2LMNAKMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11866401-B2 | Salicyl fumarate derivative and its application in the treatment of Parkinson's disease and other neurodegenerative diseases | CHONGQING NEUROPARK BIOSCIENCE CO., LTD. (CN) | 2024-01-09 | — | — | US | claimed |
| US-20210179533-A1 | SALICYL FUMARATE DERIVATIVE AND ITS APPLICATION IN THE TREATMENT OF PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES | CHONGQING NEUROPARK BIOSCIENCE CO., LTD. (CN) | 2021-06-17 | — | — | US | claimed |
| EP-3611157-A1 | SALICYLIC ACID-BASED FUMARATE DERIVATIVE AND USE IN TREATMENT OF PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES | Chongqing Neuropark Bioscience Co., Ltd. (CN) | 2020-02-19 | — | — | EP | claimed |
| US-20200048182-A1 | A SALICYL FUMARATE DERIVATIVE AND ITS APPLICATION IN THE TREATMENT OF PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES | CHONGQING NEUROPARK BIOSCIENCE CO., LTD. (CN) | 2020-02-13 | — | — | US | claimed |
| US-11866401-B2 | Salicyl fumarate derivative and its application in the treatment of Parkinson's disease and other neurodegenerative diseases | CHONGQING NEUROPARK BIOSCIENCE CO., LTD. (CN) | 2024-01-09 | — | — | US | disclosed |
| US-20210179533-A1 | SALICYL FUMARATE DERIVATIVE AND ITS APPLICATION IN THE TREATMENT OF PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES | CHONGQING NEUROPARK BIOSCIENCE CO., LTD. (CN) | 2021-06-17 | — | — | US | disclosed |
| EP-3611157-A1 | SALICYLIC ACID-BASED FUMARATE DERIVATIVE AND USE IN TREATMENT OF PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES | Chongqing Neuropark Bioscience Co., Ltd. (CN) | 2020-02-19 | — | — | EP | disclosed |
| US-20200048182-A1 | A SALICYL FUMARATE DERIVATIVE AND ITS APPLICATION IN THE TREATMENT OF PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES | CHONGQING NEUROPARK BIOSCIENCE CO., LTD. (CN) | 2020-02-13 | — | — | US | disclosed |
| CN-106946701-A | Salicylic acid-based fumarate derivative and application thereof in treating Parkinson's disease and other neurodegenerative diseases | 杨立川 | 2017-07-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210179533-A1 | SALICYL FUMARATE DERIVATIVE AND ITS APPLICATION IN THE TREATMENT OF PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES | FH, SUCNR1, SDHB | SMN1; SMN2 84/4885LMNA 3919/4885ABCG2 508/4885 |
| US-20200048182-A1 | A SALICYL FUMARATE DERIVATIVE AND ITS APPLICATION IN THE TREATMENT OF PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES | FH, SUCNR1, SDHB | SMN1; SMN2 101/4885LMNA 3665/4885ABCG2 497/4885 |
| US-11866401-B2 | Salicyl fumarate derivative and its application in the treatment of Parkinson's disease and other neurodegenerative diseases | FH, SUCNR1, SDHB | SMN1; SMN2 64/4885LMNA 3895/4885ABCG2 482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.