Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19080610 | 0.80 | KDM4E (0.54) | LMNATDP1TSHRALDH1A1HRH3 | |
| SCHEMBL14297823 | 0.78 | AURKA (0.48) | LMNAAURKADHFRTSHRALDH1A1 | |
| SCHEMBL8910376 | 0.76 | HPGD (0.54) | LMNAAURKADHFRTSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL21633585 | 0.76 | AURKA (0.47) | LMNAAURKADHFRTSHRALDH1A1 | |
| SCHEMBL23874468 | 0.73 | EDNRA (0.39) | ALDH1A1EDNRAKDM4EKMT2A | |
| SCHEMBL15601951 | 0.72 | KEAP1 (0.50) | LMNAALDH1A1KMT2ATAAR1 | |
| SCHEMBL21686902 | 0.71 | ALDH1A1 (0.49) | LMNATDP1TSHRALDH1A1KDM4E | |
| SCHEMBL21686843 | 0.70 | LMNA (0.57) | LMNATDP1ALDH1A1L3MBTL1HRH3 | |
| SCHEMBL12256025 | 0.69 | GLO1 (0.48) | LMNAAURKADHFRTSHRALDH1A1 | |
| SCHEMBL21686841 | 0.68 | CA12 (0.46) | TSHRALDH1A1L3MBTL1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020020939-A1 | PYRIDOPYRIMIDINES AS HISTAMINE H4-RECEPTOR INHIBITORS | FAES FARMA, S.A. (ES) | 2020-01-30 | — | — | WO | disclosed |