Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | TRIP13 | Q15645 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2169652 | 0.87 | HSD11B1 (0.43) | SMN1; SMN2HSD11B1ALDH1A1MEN1KMT2A | |
| SCHEMBL2168984 | 0.86 | LMNA (0.36) | SMN1; SMN2HSD11B1MEN1KMT2AGAA | |
| SCHEMBL2170264 | 0.86 | CXCR3 (0.40) | SMN1; SMN2HSD11B1ALDH1A1P2RX7CYP3A4 | |
| SCHEMBL2169468 | 0.85 | ACHE (0.35) | HSD11B1ALDH1A1P2RX7KDM4E | |
| SCHEMBL2168961 | 0.85 | CYP11B2 (0.37) | SMN1; SMN2HSD11B1ALDH1A1MEN1KMT2A | |
| SCHEMBL2169304 | 0.84 | CYP3A4 (0.37) | HSD11B1ALDH1A1CYP3A4KDM4E | |
| SCHEMBL12013028 | 0.82 | HSD11B1 (0.30) | HSD11B1 | |
| SCHEMBL2168763 | 0.82 | POLB (0.38) | HSD11B1ALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL2170139 | 0.81 | HSD11B1 (0.40) | HSD11B1ALDH1A1MEN1KMT2ACYP2C9 | |
| SCHEMBL2168957 | 0.80 | BACE1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2348019-A1 | 1,2-DIAZETIDIN-3-ONE DERIVATIVE AND PHARMACEUTICAL AGENT COMPRISING SAME | Kowa Company, Ltd. (JP) | 2011-07-27 | — | — | EP | disclosed |