SCHEMBL21695049

SCHEMBL21695049

CC(C)n1ncc2c(NC(=O)c3ccccc3)ncnc21

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.46
TP53 P04637 4/20 0.46
LMNA P02545 3/20 0.46
RET P07949 1/20 0.46
KDR P35968 1/20 0.46
ALDH1A1 P00352 3/20 0.45
NPC1 O15118 3/20 0.45
RAB9A P51151 3/20 0.45
SMN1; SMN2 Q16637 3/20 0.45
HPGD P15428 2/20 0.45
HSD17B10 Q99714 2/20 0.45
TSHR P16473 1/20 0.45
POLB P06746 2/20 0.45
MAPT P10636 6/20 0.45
SIGMAR1 Q99720 1/20 0.44
KDM4E B2RXH2 2/20 0.44
MEN1 O00255 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14438659 0.84 MAPT (0.62) TP53LMNAALDH1A1NPC1RAB9A
SCHEMBL3784641 0.81 MAPK14 (0.55) BRD4TP53LMNARETKDR
SCHEMBL28393556 0.80 MAPT (0.65) TP53LMNAALDH1A1NPC1RAB9A
SCHEMBL28888396 0.75 LMNA (0.64) TP53LMNAALDH1A1NPC1RAB9A
SCHEMBL31320738 0.75 RAB9A (0.50) TP53LMNAKDRNPC1RAB9A
SCHEMBL14438661 0.74 BRD4 (0.47) BRD4RETKDRCYP3A4
SCHEMBL24393418 0.74 TP53 (0.49) TP53LMNAALDH1A1NPC1RAB9A
SCHEMBL2718523 0.74 CDK1 (0.59) NPC1POLBMAPK1
SCHEMBL13057332 0.73 FLT3 (0.49) TP53LMNAALDH1A1NPC1RAB9A
SCHEMBL28888394 0.73 ALDH1A1 (0.66) TP53LMNAALDH1A1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10875880-B2 Processes for preparing oligomers SAREPTA THERAPEUTICS, INC. (US) 2020-12-29 US disclosed
US-20200040020-A1 PROCESSES FOR PREPARING OLIGOMERS JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2020-02-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200040020-A1 PROCESSES FOR PREPARING OLIGOMERS NOP2, PCBP1, RNGTT BRD4 4222/4885TP53 2210/4885LMNA 1421/4885
US-10875880-B2 Processes for preparing oligomers NOP2, PCBP1, RNGTT BRD4 4222/4885TP53 2210/4885LMNA 1421/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.