Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 10/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD11B2 | P80365 | 3/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.37 |
| ▸ | CHRNA6 | Q15825 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21696767 | 0.71 | ALDH1A1 (0.48) | TSHRGAAHSD11B1ALDH1A1HSD11B2 | |
| SCHEMBL14327371 | 0.66 | ALDH1A1 (0.67) | TSHRHSD11B1ALDH1A1HSD11B2CHRNB2 | |
| SCHEMBL9667146 | 0.64 | TSHR (0.96) | TSHRGAAHSD11B1ALDH1A1HSD11B2 | |
| SCHEMBL17048669 | 0.62 | HSD11B1 (0.34) | TSHRHSD11B1 | |
| SCHEMBL9667551 | 0.62 | GAA (0.95) | TSHRGAAHSD11B1ALDH1A1HSD11B2 | |
| SCHEMBL27879619 | 0.61 | TSHR (0.44) | TSHRGAAHSD11B1ALDH1A1HSD11B2 | |
| SCHEMBL21945481 | 0.61 | TSHR (0.54) | TSHRGAAHSD11B1ALDH1A1HSD11B2 | |
| SCHEMBL14327358 | 0.61 | ALDH1A1 (0.44) | TSHRGAAHSD11B1ALDH1A1HSD11B2 | |
| SCHEMBL28307419 | 0.60 | GAA (0.51) | TSHRGAAHSD11B1ALDH1A1CHRNB2 | |
| SCHEMBL30060822 | 0.59 | ALDH1A1 (0.55) | TSHRHSD11B1ALDH1A1HSD11B2CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3608317-A1 | COMPOUNDS & METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS & OTHER POLYPEPTIDES BY AN E3 UBIQUITIN LIGASE | Yale University (US) | 2020-02-12 | — | — | EP | disclosed |