SCHEMBL216975

SCHEMBL216975

FC(F)(F)c1cccc(C2=Cc3ccccc3[CH]2)c1C(F)(F)F

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 3/20 0.44
CNR2 P34972 1/20 0.35
PDK2 Q15119 1/20 0.34
NOTUM Q6P988 4/20 0.33
CES1 P23141 1/20 0.33
GPR3 P46089 1/20 0.31
SCN9A Q15858 2/20 0.31
C1R P00736 1/20 0.31
ALDH1A1 P00352 2/20 0.30
HPGD P15428 1/20 0.30
AR P10275 1/20 0.30
KIF11 P52732 1/20 0.30
POLB P06746 1/20 0.30
TDP1 Q9NUW8 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2972102 0.86 HSD11B1 (0.41) HSD11B1PDK2NOTUMGPR3C1R
SCHEMBL6067687 0.75 HSD11B1 (0.55) HSD11B1CNR2PDK2NOTUMCES1
SCHEMBL216974 0.75 HSD11B1 (0.49) HSD11B1CNR2PDK2NOTUMCES1
SCHEMBL2597833 0.71 HSD11B1 (0.51) HSD11B1CNR2PDK2CES1SCN9A
SCHEMBL217868 0.69 EED (0.36) NOTUMC1RALDH1A1L3MBTL1
SCHEMBL2000756 0.69 HSD11B1 (0.46) HSD11B1CNR2PDK2CES1ALDH1A1
SCHEMBL646458 0.68 HSD11B1 (0.49) HSD11B1CNR2PDK2NOTUMCES1
SCHEMBL2969666 0.68 HSD11B1 (0.33) HSD11B1CES1
SCHEMBL28223418 0.68 HSD11B1 (0.49) HSD11B1CNR2PDK2SCN9AALDH1A1
Lithium SCHEMBL5691154 0.66 HSD11B1 (0.44) HSD11B1CNR2PDK2CES1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10421921-B2 Lubricants from mixed alpha-olefin feeds EXXONMOBIL CHEMICAL PATENTS INC. (US) 2019-09-24 US disclosed
EP-1920031-B1 LUBRICANTS FROM MIXED ALPHA-OLEFIN FEEDS EXXONMOBIL CHEMICAL PATENTS INC (US) 2018-01-10 EP disclosed
US-20170137737-A1 Lubricants from Mixed Alpha-Olefin Feeds EXXONMOBIL CHEMICAL PATENTS INC. 2017-05-18 US disclosed
US-9593288-B2 Lubricants from mixed alpha-olefin feeds EXXONMOBIL CHEMICAL PATENTS INC. (US) 2017-03-14 US disclosed
US-9409834-B2 Low viscosity poly-alpha-olefins EXXONMOBIL CHEMICAL PATENTS INC. (US) 2016-08-09 US disclosed
US-20150252279-A1 Lubricants From Mixed Alpha-Olefin Feeds EXXONMOBIL CHEMICAL PATENTS INC. 2015-09-10 US disclosed
US-8957159-B2 Multiple catalyst system for olefin polymerization and polymers produced therefrom EXXONMOBIL CHEMICAL PATENTS INC. (US) 2015-02-17 US disclosed
US-8921291-B2 Lubricants from mixed alpha-olefin feeds EXXONMOBIL CHEMICAL PATENTS INC. (US) 2014-12-30 US disclosed
US-20140378720-A1 Processes to Produce Polyalpha-Olefin Compositions EXXONMOBIL CHEMICAL PATENTS INC. 2014-12-25 US disclosed
EP-1910432-B1 PROCESS TO PRODUCE LOW VISCOSITY POLY-ALPHA-OLEFINS EXXONMOBIL CHEM PATENTS INC (US) 2014-11-12 EP disclosed
US-20090036725-A1 Process To Produce Polyalphaolefins EXXONMOBIL CHEMICAL PATENTS INC. 2009-02-05 US disclosed
WO-2009017953-A2 PROCESS TO PRODUCE POLYALPHAOLEFINS EXXONMOBIL CHEMICAL PATENT INC. (US) 2009-02-05 WO disclosed
US-20090005279-A1 Polyalpha-Olefin Compositions and Processes to Produce the Same EXXONMOBIL CHEMICAL PATENTS INC. 2009-01-01 US disclosed
WO-2008140875-A1 CATALYST SYSTEM FOR OLEFIN POLYMERIZATION AND POLYMERS PRODUCED THEREFROM EXXONMOBIL CHEMICAL PATENTS INC. (US) 2008-11-20 WO disclosed
US-20080287617-A1 Catalyst System For Olefin Polymerization And Polymers Produced Therefrom EXXONMOBIL CHEMICAL PATENTS INC. 2008-11-20 US disclosed
US-20080177121-A1 Process to produce high viscosity fluids EXXONMOBIL CHEMICAL PATENTS INC. 2008-07-24 US disclosed
US-20070293640-A1 Multiple catalyst system for olefin polymerization and polymers produced therefrom EXXONMOBIL CHEMICAL PATENTS INC. 2007-12-20 US disclosed
US-7294681-B2 Mutliple catalyst system for olefin polymerization and polymers produced therefrom EXXONMOBIL CHEMICAL PATENTS INC. (US) 2007-11-13 US disclosed
US-7223822-B2 Multiple catalyst and reactor system for olefin polymerization and polymers produced therefrom EXXONMOBIL CHEMICAL PATENTS INC. (US) 2007-05-29 US disclosed
US-20070043248-A1 Process to produce low viscosity poly-alpha-olefins EXXONMOBIL CHEMICAL PATENTS INC. 2007-02-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090036725-A1 Process To Produce Polyalphaolefins KCNMA1, F10, AP2A1 HSD11B1 1919/4885CNR2 2777/4885PDK2 3825/4885
US-20070043248-A1 Process to produce low viscosity poly-alpha-olefins AP1M1, AP3D1, AP3M1 HSD11B1 2579/4885CNR2 3281/4885PDK2 3774/4885
US-20080177121-A1 Process to produce high viscosity fluids SCO2, POLI, TAOK1 HSD11B1 2471/4885CNR2 3887/4885PDK2 2762/4885
US-20140378720-A1 Processes to Produce Polyalpha-Olefin Compositions AP1M1, AP1S1, CCT4 HSD11B1 1291/4885CNR2 3024/4885PDK2 4431/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.