Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 6/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | PPARD | Q03181 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | HPGDS | O60760 | 2/20 | 0.44 |
| ▸ | PHGDH | O43175 | 1/20 | 0.43 |
| ▸ | GALR3 | O60755 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KCNT1 | Q5JUK3 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21683294 | 0.88 | L3MBTL1 (0.47) | HDAC4HDAC6HDAC1PPARGPPARD | |
| SCHEMBL19463739 | 0.81 | HDAC4 (0.59) | HDAC4HDAC6HDAC1HDAC8HDAC5 | |
| SCHEMBL29627668 | 0.75 | HDAC4 (0.53) | HDAC4HDAC6HDAC1HDAC8HDAC5 | |
| SCHEMBL21683292 | 0.74 | HDAC6 (0.57) | HDAC4HDAC6HDAC1PPARAHPGDS | |
| SCHEMBL21702522 | 0.74 | L3MBTL1 (0.52) | HDAC4HDAC6HDAC1PPARGPPARD | |
| SCHEMBL21702505 | 0.73 | L3MBTL1 (0.43) | PPARGPPARDPPARAPHGDHGALR3 | |
| SCHEMBL29058586 | 0.72 | HDAC4 (0.53) | HDAC4HDAC6HDAC1KCNT1 | |
| SCHEMBL20108994 | 0.72 | L3MBTL1 (0.49) | PPARGPPARDPPARAPHGDHGALR3 | |
| SCHEMBL30848707 | 0.71 | HDAC4 (0.51) | HDAC4HDAC6HDAC1HPGDSL3MBTL1 | |
| SCHEMBL19462981 | 0.67 | HDAC4 (0.57) | HDAC4HDAC6HDAC1HDAC8HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12486255-B2 | Modulators of RAS GTPase | TOSK, INC. (US) | 2025-12-02 | — | — | US | disclosed |
| US-20240279206-A1 | Modulators of RAS GTPase | TOSK, INC. | 2024-08-22 | — | — | US | disclosed |
| WO-2020033413-A2 | MODULATORS OF RAS GTPASE | TOSK, INC. (US) | 2020-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12486255-B2 | Modulators of RAS GTPase | KRAS, HRAS, NRAS | HDAC4 1731/4885HDAC6 785/4885HDAC1 1538/4885 |
| US-20240279206-A1 | Modulators of RAS GTPase | KRAS, HRAS, NRAS | HDAC4 1731/4885HDAC6 785/4885HDAC1 1538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.