Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | PHGDH | O43175 | 1/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21683294 | 0.86 | L3MBTL1 (0.47) | L3MBTL1PHGDHPLK1MAPTPOLB | |
| SCHEMBL21702506 | 0.83 | L3MBTL1 (0.52) | L3MBTL1PLK1MAPTPOLBKMT2A | |
| SCHEMBL9195354 | 0.79 | L3MBTL1 (0.64) | L3MBTL1PHGDHMAPTPOLBKMT2A | |
| SCHEMBL21683299 | 0.78 | PLK1 (0.58) | PLK1MAPTPOLBKMT2AHDAC6 | |
| SCHEMBL23780470 | 0.78 | HDAC6 (0.62) | PLK1HDAC6HDAC4HDAC1LMNA | |
| SCHEMBL23291895 | 0.77 | PLK1 (0.57) | PLK1MAPTPOLBKMT2AHDAC6 | |
| SCHEMBL23791596 | 0.75 | PLK1 (0.55) | PLK1MAPTPOLBKMT2AHDAC4 | |
| SCHEMBL19463739 | 0.75 | HDAC4 (0.59) | HDAC6HDAC4HDAC1HDAC8 | |
| SCHEMBL23292063 | 0.74 | HDAC1 (0.48) | PLK1MAPTPOLBKMT2AHDAC6 | |
| SCHEMBL21702468 | 0.74 | HDAC4 (0.46) | L3MBTL1PHGDHHDAC6HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033413-A2 | MODULATORS OF RAS GTPASE | TOSK, INC. (US) | 2020-02-13 | — | — | WO | disclosed |