Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KCNT1 | Q5JUK3 | 3/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | PPARD | Q03181 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | PHGDH | O43175 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21702468 | 0.88 | HDAC4 (0.46) | L3MBTL1KCNT1PPARGPPARDPPARA | |
| SCHEMBL21702522 | 0.86 | L3MBTL1 (0.52) | L3MBTL1PLK1CTSLCTSBCTSS | |
| SCHEMBL21702506 | 0.78 | L3MBTL1 (0.52) | L3MBTL1PLK1POLBKMT2AMAPT | |
| SCHEMBL19463739 | 0.76 | HDAC4 (0.59) | HDAC1HDAC6HDAC4 | |
| SCHEMBL20108994 | 0.76 | L3MBTL1 (0.49) | L3MBTL1PPARGPPARDPPARAPHGDH | |
| SCHEMBL21702505 | 0.76 | L3MBTL1 (0.43) | L3MBTL1PPARGPPARDPPARAPHGDH | |
| SCHEMBL21683299 | 0.74 | PLK1 (0.58) | PLK1CTSLCTSBCTSSCTSK | |
| SCHEMBL23780470 | 0.73 | HDAC6 (0.62) | PLK1PPARALMNAHDAC1HDAC6 | |
| SCHEMBL23291895 | 0.73 | PLK1 (0.57) | PLK1CTSLCTSBCTSSCTSK | |
| SCHEMBL8252393 | 0.71 | S1PR1 (0.56) | L3MBTL1PLK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12486255-B2 | Modulators of RAS GTPase | TOSK, INC. (US) | 2025-12-02 | — | — | US | disclosed |
| US-20240279206-A1 | Modulators of RAS GTPase | TOSK, INC. | 2024-08-22 | — | — | US | disclosed |
| US-11945803-B2 | Modulators of RAS GTPase | TOSK, INC. (US) | 2024-04-02 | — | — | US | disclosed |
| WO-2020033413-A2 | MODULATORS OF RAS GTPASE | TOSK, INC. (US) | 2020-02-13 | — | — | WO | disclosed |
| WO-2020033413-A2 | MODULATORS OF RAS GTPASE | TOSK, INC. (US) | 2020-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12486255-B2 | Modulators of RAS GTPase | KRAS, HRAS, NRAS | L3MBTL1 3281/4885KCNT1 4402/4885PLK1 123/4885 |
| US-11945803-B2 | Modulators of RAS GTPase | KRAS, HRAS, NRAS | L3MBTL1 3281/4885KCNT1 4402/4885PLK1 123/4885 |
| US-20240279206-A1 | Modulators of RAS GTPase | KRAS, HRAS, NRAS | L3MBTL1 3281/4885KCNT1 4402/4885PLK1 123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.