Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 2/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21703985 | 0.85 | LIMK1 (0.34) | KDM4EALDH1A1SMN1; SMN2LMNANOS1 | |
| SCHEMBL20731982 | 0.71 | ALDH1A1 (0.62) | KDM4EALDH1A1SMN1; SMN2LMNAIKBKB | |
| SCHEMBL23938014 | 0.67 | LIMK1 (0.33) | KDM4EALDH1A1SMN1; SMN2NOS1IKBKB | |
| SCHEMBL20731141 | 0.67 | USP25 (0.38) | — | |
| SCHEMBL16919863 | 0.67 | GPR3 (0.45) | KDM4EALDH1A1SMN1; SMN2LMNALIMK1 | |
| SCHEMBL5534850 | 0.67 | SMN1; SMN2 (0.41) | ALDH1A1SMN1; SMN2LMNANOS1NPC1 | |
| SCHEMBL20731139 | 0.65 | IKBKB (0.37) | KDM4EALDH1A1SMN1; SMN2NOS1IKBKB | |
| SCHEMBL17813446 | 0.64 | PDK2 (0.32) | PDK2 | |
| SCHEMBL3445191 | 0.64 | PDK2 (0.32) | ALDH1A1SMN1; SMN2MAPTHSD17B10PDK2 | |
| SCHEMBL20731980 | 0.63 | USP28 (0.39) | KDM4EALDH1A1SMN1; SMN2IKBKBLIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033707-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2020-02-13 | — | — | WO | disclosed |