Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KLK7 | P49862 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 3/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2185321 | 0.86 | IDO1 (0.47) | MEN1HPGDKMT2AKLK7IDO1 | |
| SCHEMBL13421671 | 0.83 | KMT2A (0.50) | MEN1HPGDKMT2AIDO1HSD11B1 | |
| SCHEMBL1372968 | 0.82 | S1PR1 (0.57) | MEN1HPGDKMT2AIDO1HSD11B1 | |
| SCHEMBL2170390 | 0.81 | SMN1; SMN2 (0.56) | MEN1HPGDKMT2AS1PR1ALDH1A1 | |
| SCHEMBL2173707 | 0.80 | MEN1 (0.50) | MEN1HPGDKMT2AALDH1A1LMNA | |
| SCHEMBL2171615 | 0.78 | ALDH1A1 (0.51) | MEN1HPGDKMT2AS1PR1ALDH1A1 | |
| SCHEMBL2171842 | 0.78 | ALDH1A1 (0.64) | MEN1HPGDKMT2AALDH1A1MAPT | |
| SCHEMBL2169800 | 0.78 | ALDH1A1 (0.51) | MEN1HPGDKMT2AS1PR1ALDH1A1 | |
| SCHEMBL2170428 | 0.77 | ALDH1A1 (0.47) | MEN1HPGDKMT2AS1PR1ALDH1A1 | |
| SCHEMBL3132407 | 0.77 | ALDH1A1 (0.46) | MEN1HPGDKMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349252-A2 | SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS | Exelixis, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |