Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2170390 | 0.88 | SMN1; SMN2 (0.56) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL2185321 | 0.85 | IDO1 (0.47) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL2171842 | 0.83 | ALDH1A1 (0.64) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL2171615 | 0.83 | ALDH1A1 (0.51) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL2169800 | 0.83 | ALDH1A1 (0.51) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL1375086 | 0.81 | S1PR1 (0.57) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL1375081 | 0.81 | S1PR1 (0.57) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL3132407 | 0.81 | ALDH1A1 (0.46) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL2170963 | 0.80 | MEN1 (0.48) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL2170428 | 0.80 | ALDH1A1 (0.47) | MEN1KMT2AHPGDALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |