Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.62 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.62 |
| ▸ | FNTA | P49354 | 4/20 | 0.62 |
| ▸ | FNTB | P49356 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | RNF4 | P78317 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | PNLIP | P16233 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4621713 | 0.89 | KMT2A (0.77) | ALDH1A1MEN1KMT2AMAPTTSHR | |
| SCHEMBL2170925 | 0.85 | MTNR1B (0.73) | L3MBTL1ALDH1A1MEN1KMT2AMTNR1A | |
| SCHEMBL14447211 | 0.85 | MTNR1A (0.64) | L3MBTL1ALDH1A1MEN1KMT2AMTNR1A | |
| SCHEMBL21392968 | 0.85 | RNF4 (0.76) | L3MBTL1ALDH1A1MEN1KMT2AFNTA | |
| SCHEMBL2172248 | 0.85 | MTNR1A (0.64) | L3MBTL1ALDH1A1MEN1KMT2AMTNR1A | |
| SCHEMBL2173035 | 0.85 | MTNR1A (0.73) | L3MBTL1ALDH1A1MEN1KMT2AMTNR1A | |
| SCHEMBL2169725 | 0.85 | MTNR1A (0.78) | L3MBTL1ALDH1A1KMT2AMTNR1AMTNR1B | |
| SCHEMBL2171478 | 0.84 | ESRRA (0.64) | MAPTTSHRCYP3A4PNLIP | |
| SCHEMBL4747363 | 0.83 | ALDH1A1 (0.64) | L3MBTL1ALDH1A1MEN1KMT2AFNTA | |
| SCHEMBL2170997 | 0.83 | MTNR1A (0.62) | L3MBTL1ALDH1A1MEN1KMT2AMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349252-A2 | SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS | Exelixis, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |