Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | PDE2A | O00408 | 9/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | CCR9 | P51686 | 2/20 | 0.33 |
| ▸ | PDE6D | O43924 | 2/20 | 0.33 |
| ▸ | PDE6A | P16499 | 2/20 | 0.33 |
| ▸ | PDE6G | P18545 | 2/20 | 0.33 |
| ▸ | PDE6B | P35913 | 2/20 | 0.33 |
| ▸ | PDE6C | P51160 | 2/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE6H | Q13956 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18668223 | 0.85 | HPGD (0.38) | HPGDTSHRSMN1; SMN2HSD17B10RAB9A | |
| SCHEMBL22949459 | 0.78 | CA1 (0.36) | HPGDALDH1A1PDE2APDE10APOLB | |
| SCHEMBL22570331 | 0.76 | POLB (0.34) | TSHRPDE2APDE10APOLBTDP1 | |
| SCHEMBL21719172 | 0.76 | POLB (0.34) | ALDH1A1PDE10APOLBTDP1SIRT2 | |
| SCHEMBL11955243 | 0.76 | ALOX15 (0.39) | HPGDHSD17B10ALDH1A1HTTPOLB | |
| SCHEMBL24709252 | 0.75 | S1PR4 (0.31) | — | |
| SCHEMBL18676759 | 0.74 | TDP1 (0.38) | HPGDSMN1; SMN2HSD17B10RAB9AALDH1A1 | |
| SCHEMBL14372218 | 0.74 | MTNR1A (0.37) | HPGDTSHRSMN1; SMN2HSD17B10RAB9A | |
| SCHEMBL13990317 | 0.74 | CRHBP (0.39) | TSHRRIPK2 | |
| SCHEMBL29581181 | 0.74 | HPGD (0.40) | HPGDTSHRSMN1; SMN2HSD17B10RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753393-B2 | Dihydroorotate dehydrogenase inhibitors | JANSSEN BIOTECH, INC. | 2023-09-12 | — | — | US | disclosed |
| US-11753393-B2 | Dihydroorotate dehydrogenase inhibitors | JANSSEN BIOTECH, INC. | 2023-09-12 | — | — | US | disclosed |
| US-20220298137-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | JANSSEN BIOTECH INC (US) | 2022-09-22 | — | — | US | disclosed |
| US-11178870-B2 | Pyridone compounds and agricultural and horticultural fungicides containing the same as active ingredients | MITSUI CHEMICALS AGRO, INC. (JP) | 2021-11-23 | — | — | US | disclosed |
| US-20200331881-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | JANSSEN BIOTECH, INC. | 2020-10-22 | — | — | US | disclosed |
| US-20200045968-A1 | PYRIDONE COMPOUNDS AND AGRICULTURAL AND HORTICULTURAL FUNGICIDES CONTAINING THE SAME AS ACTIVE INGREDIENTS | MITSUI CHEMICALS AGRO, INC. (JP) | 2020-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11753393-B2 | Dihydroorotate dehydrogenase inhibitors | DHODH, DLD, DPYD | HPGD 54/4885TSHR 4034/4885SMN1; SMN2 3587/4885 |
| US-20220298137-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | DHODH, DLD, DPYD | HPGD 54/4885TSHR 4034/4885SMN1; SMN2 3587/4885 |
| US-11178870-B2 | Pyridone compounds and agricultural and horticultural fungicides containing the same as active ingredients | PNPO, CYP4X1, PDXK | HPGD 159/4885TSHR 2711/4885SMN1; SMN2 3624/4885 |
| US-20200331881-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | DHODH, DLD, DPYD | HPGD 54/4885TSHR 4034/4885SMN1; SMN2 3587/4885 |
| US-20200045968-A1 | PYRIDONE COMPOUNDS AND AGRICULTURAL AND HORTICULTURAL FUNGICIDES CONTAINING THE SAME AS ACTIVE INGREDIENTS | PNPO, CYP4X1, PDXK | HPGD 159/4885TSHR 2711/4885SMN1; SMN2 3624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.