Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | CASP7 | P55210 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30528247 | 0.80 | KDM4E (0.44) | KDM4EALDH1A1HPGDGLASMN1; SMN2 | |
| SCHEMBL15058512 | 0.80 | KDM4E (0.44) | KDM4EALDH1A1HPGDGLASMN1; SMN2 | |
| SCHEMBL28360035 | 0.78 | KDM4E (0.43) | KDM4EALDH1A1HPGDGLASMN1; SMN2 | |
| SCHEMBL2512737 | 0.77 | KDM4E (0.56) | KDM4EALDH1A1HPGDGLASMN1; SMN2 | |
| SCHEMBL30918027 | 0.75 | ACHE (0.61) | KDM4EALDH1A1HPGDGLASMN1; SMN2 | |
| SCHEMBL538767 | 0.75 | KDM4E (0.40) | KDM4EALDH1A1HPGDGLASMN1; SMN2 | |
| SCHEMBL538014 | 0.75 | MAOA (0.61) | KDM4EALDH1A1HPGDGLASMN1; SMN2 | |
| SCHEMBL13943889 | 0.75 | ALDH1A1 (0.49) | KDM4EALDH1A1HPGDGLASMN1; SMN2 | |
| Bicarbonate SCHEMBL10810371 | 0.73 | SMN1; SMN2 (0.42) | KDM4EALDH1A1HPGDGLASMN1; SMN2 | |
| SCHEMBL7523835 | 0.73 | GPR3 (0.54) | KDM4EALDH1A1HPGDGLASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346830-A1 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | Merck Sharp & Dohme Corp. (US) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010030722-A1 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK SHARP & DOHME CORP. (US) | 2010-03-18 | — | — | WO | disclosed |