Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 7/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | FABP2 | P12104 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2170716 | 0.88 | AKR1C3 (0.45) | AKR1C3AKR1C2PTGS2PTGS1MAPT | |
| SCHEMBL7372312 | 0.82 | KMT2A (0.47) | MAPTCYP1A2CYP2C9CYP2C19LMNA | |
| SCHEMBL6973224 | 0.77 | PPARA (0.43) | MAPTCYP1A2CYP2C9CYP2C19LMNA | |
| SCHEMBL12167639 | 0.77 | AKR1C3 (0.49) | AKR1C3AKR1C2 | |
| SCHEMBL3680291 | 0.76 | AKR1C3 (0.57) | AKR1C3AKR1C2PTGS2PTGS1CYP1A2 | |
| SCHEMBL6982722 | 0.76 | KEAP1 (0.45) | AKR1C3AKR1C2MAPTCYP1A2CYP2C9 | |
| SCHEMBL2172516 | 0.75 | KIF11 (0.64) | AKR1C3AKR1C2PTGS2PTGS1MAPT | |
| SCHEMBL2818448 | 0.75 | KIF11 (0.64) | AKR1C3AKR1C2PTGS2PTGS1MAPT | |
| SCHEMBL31213428 | 0.74 | SLC1A3 (0.54) | MAPTCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL31226789 | 0.74 | MEN1 (0.67) | MAPTLMNAMEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346841-A2 | 2-ARYL-PROPIONIC ACIDS AND DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dompe S.p.A. (IT) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010031835-A2 | 2-ARYL-PROPIONIC ACIDS AND DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE' S.P.A. (IT) | 2010-03-25 | — | — | WO | disclosed |