Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 12/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 12/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | CDC42 | P60953 | 1/20 | 0.40 |
| ▸ | RAC1 | P63000 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172054 | 0.88 | AKR1C3 (0.48) | AKR1C3AKR1C2PTGS2PTGS1CYP1A2 | |
| SCHEMBL2815572 | 0.76 | NR1H4 (0.54) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL2170471 | 0.76 | NR1H4 (0.54) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL18550691 | 0.75 | ALDH1A1 (0.48) | CYP1A2MEN1ALDH1A1LMNAMAPT | |
| SCHEMBL12167639 | 0.75 | AKR1C3 (0.49) | AKR1C3AKR1C2 | |
| SCHEMBL3680291 | 0.73 | AKR1C3 (0.57) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL5453987 | 0.72 | MEN1 (0.57) | CYP1A2MEN1ALDH1A1HTTKMT2A | |
| SCHEMBL30817854 | 0.72 | MEN1 (0.57) | CYP1A2MEN1ALDH1A1HTTKMT2A | |
| SCHEMBL18550668 | 0.71 | GAA (0.49) | CYP1A2MEN1ALDH1A1LMNAMAPT | |
| SCHEMBL30526268 | 0.71 | AKR1C3 (0.54) | AKR1C3AKR1C2PTGS2PTGS1CDC42 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8624036-B2 | 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them | DOMPE S.P.A. (IT) | 2014-01-07 | — | — | US | disclosed |
| US-20110207785-A1 | 2-Aryl-Propionic Acids and Derivatives and Pharmaceutical Compositions Containing Them | DOMPE S.P.A. (IT) | 2011-08-25 | — | — | US | disclosed |
| EP-2346841-A2 | 2-ARYL-PROPIONIC ACIDS AND DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dompe S.p.A. (IT) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010031835-A2 | 2-ARYL-PROPIONIC ACIDS AND DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE' S.P.A. (IT) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207785-A1 | 2-Aryl-Propionic Acids and Derivatives and Pharmaceutical Compositions Containing Them | CXCR3, F2RL1, FPR2 | AKR1C3 1118/4885AKR1C2 2130/4885PTGS2 116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.