Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 7/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21723160 | 0.86 | HDAC1 (0.40) | TAAR1SLC6A9MAOBMAOAJAK2 | |
| SCHEMBL21732101 | 0.83 | JAK2 (0.38) | SLC6A9MAOBMAOAJAK2NTRK1 | |
| SCHEMBL21732252 | 0.78 | NTRK1 (0.48) | SLC6A9JAK2NTRK1NOS3RIPK1 | |
| SCHEMBL21732255 | 0.78 | NTRK1 (0.48) | SLC6A9JAK2NTRK1NOS3RIPK1 | |
| SCHEMBL21723222 | 0.78 | NTRK1 (0.48) | SLC6A9JAK2NTRK1NOS3RIPK1 | |
| SCHEMBL21732202 | 0.76 | NTRK1 (0.44) | TAAR1SLC6A9MAOBMAOAJAK2 | |
| SCHEMBL21723531 | 0.74 | NTRK1 (0.40) | SLC6A9MAOBJAK2NTRK1RIPK1 | |
| SCHEMBL21732282 | 0.72 | NTRK1 (0.40) | SLC6A9MAOBMAOAJAK2NTRK1 | |
| SCHEMBL21732076 | 0.66 | NTRK1 (0.54) | JAK2NTRK1 | |
| SCHEMBL25323296 | 0.65 | RIPK1 (0.44) | SLC6A9MAOBMAOARIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035557-A1 | NOVEL HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA A/S (DK) | 2020-02-20 | — | — | WO | disclosed |
| WO-2020035557-A1 | NOVEL HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA A/S (DK) | 2020-02-20 | — | — | WO | disclosed |