Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | GPR3 | P46089 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | PGR | P06401 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18415206 | 0.69 | PDK2 (0.41) | MAPTKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL29099251 | 0.68 | MAPT (0.42) | MAPTKDM4EKMT2AMEN1MAPK1 | |
| SCHEMBL20952938 | 0.66 | NOTUM (0.38) | MAPTKMT2AMEN1ALDH1A1NOTUM | |
| SCHEMBL11990876 | 0.65 | MAPT (0.41) | MAPTKDM4EKMT2AMEN1MAPK1 | |
| SCHEMBL20618813 | 0.65 | ALDH1A1 (0.47) | MAPTKDM4EKMT2AMEN1MAPK1 | |
| SCHEMBL19773135 | 0.64 | MAPT (0.43) | MAPTKDM4EKMT2AMEN1MAPK1 | |
| SCHEMBL17275723 | 0.64 | ALDH1A1 (0.50) | MAPTKDM4EKMT2AMEN1MAPK1 | |
| SCHEMBL8911633 | 0.64 | LMNA (0.41) | MAPTKDM4EKMT2AMEN1MAPK1 | |
| SCHEMBL18383337 | 0.64 | PDK2 (0.44) | MAPTKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL283246 | 0.64 | HTR2A (0.48) | MAPTKDM4EKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10562933-B2 | Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity | POLYPHOR LTD. (CH) | 2020-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10562933-B2 | Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity | CTSG, CTRL, PREP | MAPT 2118/4885KDM4E 2581/4885KMT2A 1489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.