Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21774844 | 1.00 | YTHDC1 (0.48) | YTHDC1SLC6A2SLC6A4KMT2ASLC6A3 | |
| SCHEMBL3376962 | 0.85 | YTHDC1 (0.58) | YTHDC1SLC6A2SLC6A4KMT2ASLC6A3 | |
| SCHEMBL1543051 | 0.83 | YTHDC1 (0.48) | YTHDC1SLC6A2SLC6A4KMT2ASLC6A3 | |
| SCHEMBL150705 | 0.83 | YTHDC1 (0.48) | YTHDC1SLC6A2SLC6A4KMT2ASLC6A3 | |
| SCHEMBL13017781 | 0.79 | SLC6A2 (0.53) | YTHDC1SLC6A2SLC6A4KMT2ASLC6A3 | |
| SCHEMBL24126728 | 0.78 | YTHDC1 (0.44) | YTHDC1SLC6A2SLC6A4KMT2ASLC6A3 | |
| SCHEMBL24126729 | 0.78 | YTHDC1 (0.44) | YTHDC1SLC6A2SLC6A4KMT2ASLC6A3 | |
| SCHEMBL3373138 | 0.77 | SLC6A2 (0.51) | YTHDC1SLC6A2SLC6A4KMT2ASLC6A3 | |
| SCHEMBL153176 | 0.77 | YTHDC1 (0.43) | YTHDC1SLC6A2SLC6A4KMT2ASLC6A3 | |
| SCHEMBL21789675 | 0.77 | SLC6A2 (0.51) | YTHDC1SLC6A2SLC6A4KMT2ASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112566697-B | Pyrrolo [1,2-b ] pyridazine derivatives as IRAK4 inhibitors | 吉利德科学公司 | 2024-04-16 | — | — | CN | disclosed |
| US-11572362-B2 | Pyrrolo[1,2-b]pyridazine derivatives | GILEAD SCIENCES, INC. (US) | 2023-02-07 | — | — | US | disclosed |
| CN-112566697-A | Pyrrolo [1,2-b ] pyridazine derivatives as IRAK4 inhibitors | 吉利德科学公司 | 2021-03-26 | — | — | CN | disclosed |
| US-20200071333-A1 | PYRROLO[1,2-b]PYRIDAZINE DERIVATIVES | GILEAD SCIENCES, INC. | 2020-03-05 | — | — | US | disclosed |
| WO-2020036979-A1 | PYRROLO[1,2-B]PYRIDAZINE DERIVATIVES AS IRAK4 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2020-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11572362-B2 | Pyrrolo[1,2-b]pyridazine derivatives | CYP11B2, CYP11B1, DHPS | YTHDC1 4067/4885SLC6A2 2810/4885SLC6A4 3568/4885 |
| US-20200071333-A1 | PYRROLO[1,2-b]PYRIDAZINE DERIVATIVES | CYP11B2, CYP11B1, DHPS | YTHDC1 4067/4885SLC6A2 2810/4885SLC6A4 3568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.