Sugi Predict

Sugi Predict / Compounds / SCHEMBL150705

SCHEMBL150705

SCHEMBL150705

N#CC1CCC(N(Cc2ccccc2)Cc2ccccc2)CC1

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ YTHDC1 Q96MU7 1/20 0.48
▸ SLC6A2 P23975 4/20 0.44
▸ SLC6A4 P31645 4/20 0.44
▸ ALDH1A1 P00352 2/20 0.44
▸ SLC6A3 Q01959 2/20 0.41
▸ KMT2A Q03164 3/20 0.40
▸ RORC P51449 2/20 0.40
▸ MEN1 O00255 2/20 0.40
▸ GRIN2B Q13224 1/20 0.40
▸ RAB9A P51151 1/20 0.40
▸ LTA4H P09960 1/20 0.39
▸ G6PC1 P35575 1/20 0.37
▸ DRD2 P14416 1/20 0.36
▸ DRD3 P35462 1/20 0.36
▸ NAAA Q02083 1/20 0.36
▸ KDM4E B2RXH2 1/20 0.36
▸ ATM Q13315 1/20 0.36
▸ NPSR1 Q6W5P4 1/20 0.36
▸ TDP1 Q9NUW8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1543051 1.00 YTHDC1 (0.48) YTHDC1SLC6A2SLC6A4ALDH1A1SLC6A3
SCHEMBL150922 0.91 GRIN2B (0.52) YTHDC1SLC6A2SLC6A4ALDH1A1KMT2A
SCHEMBL153176 0.90 YTHDC1 (0.43) YTHDC1SLC6A2SLC6A4ALDH1A1SLC6A3
SCHEMBL3376962 0.85 YTHDC1 (0.58) YTHDC1SLC6A2SLC6A4ALDH1A1SLC6A3
SCHEMBL150082 0.83 NAAA (0.50) SLC6A4ALDH1A1RORCGRIN2BNAAA
SCHEMBL21774844 0.83 YTHDC1 (0.48) YTHDC1SLC6A2SLC6A4ALDH1A1SLC6A3
SCHEMBL21733441 0.83 YTHDC1 (0.48) YTHDC1SLC6A2SLC6A4ALDH1A1SLC6A3
SCHEMBL154511 0.82 GRIN2B (0.47) YTHDC1SLC6A2SLC6A4ALDH1A1KMT2A
SCHEMBL16751796 0.81 AGER (0.46) KMT2ARORCMEN1
SCHEMBL16751797 0.81 AGER (0.46) KMT2ARORCMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112566697-B Pyrrolo [1,2-b ] pyridazine derivatives as IRAK4 inhibitors 吉利德科学公司 2024-04-16 — — CN disclosed
US-20230159517-A1 CHROMANE AMIDINE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS MERCK SHARP & DOHME LLC (US) 2023-05-25 — — US disclosed
WO-2023091438-A1 CHROMANE AMIDINE MONOBACTAM ANTIBIOTICS MERCK SHARP & DOHME LLC (US) 2023-05-25 — — WO disclosed
US-20230159517-A1 CHROMANE AMIDINE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS MERCK SHARP & DOHME LLC (US) 2023-05-25 — — US disclosed
CN-112566697-A Pyrrolo [1,2-b ] pyridazine derivatives as IRAK4 inhibitors 吉利德科学公司 2021-03-26 — — CN disclosed
EP-2526149-B1 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORP (JP) 2017-03-01 — — EP disclosed
US-9469710-B2 Polymers functionalized with nitrile compounds containing a protected amino group BRIDGESTONE CORPORATION (JP) 2016-10-18 — — US disclosed
CN-103333275-B With the polymkeric substance of functionalized with nitrile compounds comprising protected amino BRIDGESTONE CO., LTD. (JP) 2015-07-29 — — CN disclosed
CN-103025816-B Polymers functionalized with nitrile compounds containing a protected amino group BRIDGESTONE CORP 2015-07-22 — — CN disclosed
US-20150148489-A1 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2015-05-28 — — US disclosed
US-20120296041-A1 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2012-11-22 — — US disclosed
US-20120059112-A1 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS COMTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2012-03-08 — — US disclosed
CN-102361887-A Polymers functionalized with nitrile compounds containing a protected amino group BRIDGESTONE CORP 2012-02-22 — — CN disclosed
EP-2382240-A2 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP Bridgestone Corporation (JP) 2011-11-02 — — EP disclosed
WO-2011091346-A2 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2011-07-28 — — WO disclosed
EP-2307377-A1 NICOTINAMIDE DERIVATIVES Pfizer Limited (GB) 2011-04-13 — — EP disclosed
WO-2010085622-A9 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2010-12-23 — — WO disclosed
WO-2010085622-A2 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2010-07-29 — — WO disclosed
US-20100173888-A1 Nicotinamide Derivatives PFIZER INC 2010-07-08 — — US disclosed
WO-2009153720-A1 NICOTINAMIDE DERIVATIVES PFIZER LIMITED (GB) 2009-12-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230159517-A1 CHROMANE AMIDINE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS TCOF1, SLC10A2, PAM YTHDC1 1630/4885SLC6A2 981/4885SLC6A4 2906/4885
US-20100173888-A1 Nicotinamide Derivatives NNT, NAMPT, NQO1 YTHDC1 4862/4885SLC6A2 666/4885SLC6A4 1342/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.