Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
| ▸ | FNTB | P49356 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21740219 | 0.87 | KMT2A (0.38) | ALDH1A1MAPTTSHRMEN1KMT2A | |
| SCHEMBL21740217 | 0.81 | ALDH1A1 (0.53) | ALDH1A1MAPTTSHRKMT2APOLB | |
| SCHEMBL22053233 | 0.81 | DRD2 (0.36) | ALDH1A1MAPTTSHRMEN1KMT2A | |
| SCHEMBL21739173 | 0.75 | ALDH1A1 (0.55) | ALDH1A1MAPTMEN1KMT2APOLB | |
| SCHEMBL21740228 | 0.75 | PIM1 (0.37) | ALDH1A1MAPTTSHRMEN1KMT2A | |
| SCHEMBL21739194 | 0.74 | RIPK1 (0.48) | ALDH1A1MAPTMEN1KMT2APOLB | |
| SCHEMBL21739537 | 0.73 | KMT2A (0.31) | ALDH1A1MAPTTSHRMEN1KMT2A | |
| SCHEMBL22052776 | 0.73 | HRH3 (0.36) | KMT2APKM | |
| SCHEMBL22052773 | 0.73 | KMT2A (0.33) | ALDH1A1MAPTTSHRMEN1KMT2A | |
| SCHEMBL21739728 | 0.72 | HRH4 (0.43) | ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020037079-A1 | SUBSTITUTED INDOLES AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2020-02-20 | — | — | WO | disclosed |