Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 3/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21739728 | 0.85 | HRH4 (0.43) | KMT2AGFEREPHX2ALDH1A1 | |
| SCHEMBL21739718 | 0.84 | JAK1 (0.35) | KDM1ATSHRMEN1MAPTKMT2A | |
| SCHEMBL21739719 | 0.81 | SMYD3 (0.41) | MEN1KMT2AGFERALDH1A1 | |
| SCHEMBL22053077 | 0.81 | GFER (0.36) | KMT2AGFEREPHX2ALDH1A1PKM | |
| SCHEMBL21740219 | 0.80 | KMT2A (0.38) | TSHRMEN1MAPTKMT2ANPSR1 | |
| SCHEMBL21740217 | 0.79 | ALDH1A1 (0.53) | TSHRMAPTKMT2AGFERALDH1A1 | |
| SCHEMBL21739194 | 0.78 | RIPK1 (0.48) | MEN1MAPTKMT2AALDH1A1HTT | |
| SCHEMBL21739173 | 0.75 | ALDH1A1 (0.55) | MEN1MAPTKMT2AALDH1A1HTT | |
| SCHEMBL21739722 | 0.75 | ALDH1A1 (0.37) | TSHRMEN1MAPTKMT2ANPSR1 | |
| SCHEMBL22052776 | 0.75 | HRH3 (0.36) | KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020112872-A1 | METHODS OF TREATING WHSC1-OVEREXPRESSING CANCERS BY INHIBITING SETD2 | Epizyme, Inc. (US) | 2020-06-04 | — | — | WO | disclosed |
| WO-2020037079-A1 | SUBSTITUTED INDOLES AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2020-02-20 | — | — | WO | disclosed |