Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | KLK7 | P49862 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19276941 | 1.00 | RAB9A (0.34) | RAB9ANPC1KLK7PARP1AKR1C3 | |
| SCHEMBL21739122 | 1.00 | RAB9A (0.34) | RAB9ANPC1KLK7PARP1AKR1C3 | |
| SCHEMBL17406830 | 0.89 | CHRNB2 (0.38) | RAB9ANPC1PARP1AKR1C3NOS3 | |
| SCHEMBL26053257 | 0.82 | ALDH1A1 (0.35) | RAB9ANPC1AKR1C3AKR1C2DPP4 | |
| SCHEMBL12279215 | 0.82 | ALDH1A1 (0.35) | RAB9ANPC1AKR1C3AKR1C2DPP4 | |
| SCHEMBL4331457 | 0.79 | BRD4 (0.36) | AKR1C3NOS3NOS1CHRNB2CHRNB4 | |
| SCHEMBL28508116 | 0.78 | LMNA (0.37) | RAB9ANPC1AKR1C3AKR1C2MEN1 | |
| SCHEMBL18319142 | 0.78 | LMNA (0.37) | RAB9ANPC1AKR1C3AKR1C2MEN1 | |
| SCHEMBL19277294 | 0.78 | LMNA (0.37) | RAB9ANPC1AKR1C3AKR1C2MEN1 | |
| SCHEMBL17185327 | 0.76 | AKR1C3 (0.32) | RAB9ANPC1AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020112872-A1 | METHODS OF TREATING WHSC1-OVEREXPRESSING CANCERS BY INHIBITING SETD2 | Epizyme, Inc. (US) | 2020-06-04 | — | — | WO | disclosed |
| WO-2020037079-A1 | SUBSTITUTED INDOLES AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2020-02-20 | — | — | WO | disclosed |