Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 4/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.55 |
| ▸ | RELA | Q04206 | 3/20 | 0.55 |
| ▸ | JUN | P05412 | 2/20 | 0.55 |
| ▸ | XPO1 | O14980 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | ATF1 | P18846 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1602748 | 0.84 | NFKB1 (0.46) | NFKB1NFKB2RELAJUNXPO1 | |
| SCHEMBL30110408 | 0.84 | NFKB1 (0.46) | NFKB1NFKB2RELAJUNXPO1 | |
| SCHEMBL31391972 | 0.83 | RAB9A (0.53) | NFKB1NFKB2RELAJUNSMN1; SMN2 | |
| SCHEMBL3435395 | 0.83 | RAB9A (0.53) | NFKB1NFKB2RELAJUNSMN1; SMN2 | |
| SCHEMBL8590367 | 0.81 | RAB9A (0.47) | NFKB1NFKB2RELAJUNSMN1; SMN2 | |
| SCHEMBL31584477 | 0.81 | TSHR (0.45) | NFKB1NFKB2RELAJUNSMN1; SMN2 | |
| SCHEMBL21554055 | 0.81 | TSHR (0.45) | NFKB1NFKB2RELAJUNSMN1; SMN2 | |
| SCHEMBL3056707 | 0.79 | NFKB1 (0.55) | NFKB1NFKB2RELAJUNXPO1 | |
| SCHEMBL16543696 | 0.79 | NFKB1 (0.59) | NFKB1NFKB2RELAJUNXPO1 | |
| SCHEMBL63532 | 0.79 | HPGD (0.58) | NFKB1NFKB2RELAJUNXPO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106565717-A | Synthetic method of medicine raw material methyl 2,5-difluoro-6-ethylpurine-5-carboxylate | 无锡乾浩生物医药有限公司 | 2017-04-19 | — | — | CN | claimed |
| US-12459927-B2 | Plasma kallikrein inhibitors | MERCK SHARP & DOHME LLC (US) | 2025-11-04 | — | — | US | disclosed |
| CN-115989224-B | Plasma kallikrein inhibitors | 默沙东有限责任公司 | 2025-02-25 | — | — | CN | disclosed |
| US-20230286958-A1 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-09-14 | — | — | US | disclosed |
| US-20230286958-A1 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-09-14 | — | — | US | disclosed |
| US-11672251-B2 | Herbicidally active pyridyl-/pyrimidyl-pyrimidine derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2023-06-13 | — | — | US | disclosed |
| EP-4164634-A1 | PLASMA KALLIKREIN INHIBITORS | Merck Sharp & Dohme LLC (US) | 2023-04-19 | — | — | EP | disclosed |
| CN-115989224-A | Plasma kallikrein inhibitors | 默沙东有限责任公司 | 2023-04-18 | — | — | CN | disclosed |
| EP-3863713-B1 | PHENYLTETRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2023-01-25 | — | — | EP | disclosed |
| WO-2021257353-A1 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-12-23 | — | — | WO | disclosed |
| WO-2021257353-A1 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-12-23 | — | — | WO | disclosed |
| US-20200267981-A1 | Herbicidally Active Pyridyl-/Pyrimidyl-Pyrimidine Derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2020-08-27 | — | — | US | disclosed |
| WO-2020035540-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-02-20 | — | — | WO | disclosed |
| CN-110267954-A | 1,2- pyrrolin simultaneously [3,4-c] pyridine/pyrimidine -3- ketone derivatives and the purposes that aniline replaces | 上海海雁医药科技有限公司 | 2019-09-20 | — | — | CN | disclosed |
| CN-106565717-A | Synthetic method of medicine raw material methyl 2,5-difluoro-6-ethylpurine-5-carboxylate | 无锡乾浩生物医药有限公司 | 2017-04-19 | — | — | CN | disclosed |
| CN-101663302-B | Nitrogenated fused ring derivative, pharmaceutical composition comprising the same, and use of the same for medical purposes | KISSEI PHARMACEUTICAL | 2013-07-24 | — | — | CN | disclosed |
| CN-101663302-A | Nitrogenated fused ring derivative, pharmaceutical composition comprising the same, and use of the same for medical purposes | KISSEI PHARMACEUTICAL | 2010-03-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230286958-A1 | PLASMA KALLIKREIN INHIBITORS | KLKB1, SERPINE1, KLK5 | NFKB1 712/4885NFKB2 1214/4885RELA 1972/4885 |
| US-20200267981-A1 | Herbicidally Active Pyridyl-/Pyrimidyl-Pyrimidine Derivatives | PLPBP, PDXK, DPYD | NFKB1 3880/4885NFKB2 4605/4885RELA 4593/4885 |
| US-12459927-B2 | Plasma kallikrein inhibitors | KLKB1, SERPINE1, KLK5 | NFKB1 712/4885NFKB2 1214/4885RELA 1972/4885 |
| US-11672251-B2 | Herbicidally active pyridyl-/pyrimidyl-pyrimidine derivatives | PLPBP, PDXK, DPYD | NFKB1 3880/4885NFKB2 4605/4885RELA 4593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.