SCHEMBL3056707

SCHEMBL3056707

Cc1nc(Cl)ncc1C(=O)Cl

nearest known ligand 0.55

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
NFKB1 P19838 8/20 0.55
NFKB2 Q00653 4/20 0.55
RELA Q04206 4/20 0.55
JUN P05412 3/20 0.55
XPO1 O14980 2/20 0.49
HPGD P15428 1/20 0.41
SMN1; SMN2 Q16637 3/20 0.38
ATF1 P18846 4/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
HTT P42858 2/20 0.37
LMNA P02545 1/20 0.37
AHR P35869 1/20 0.37
POLB P06746 2/20 0.36
RAB9A P51151 2/20 0.36
NPC1 O15118 1/20 0.35
MAPT P10636 1/20 0.35
GAA P10253 1/20 0.35
GFER P55789 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16543696 0.84 NFKB1 (0.59) NFKB1NFKB2RELAJUNXPO1
SCHEMBL63532 0.84 HPGD (0.58) NFKB1NFKB2RELAJUNXPO1
Hydrochloric Acid SCHEMBL10581860 0.82 HPGD (0.56) NFKB1NFKB2RELAJUNXPO1
SCHEMBL3909479 0.82 JUN (0.54) NFKB1NFKB2RELAJUNXPO1
SCHEMBL16543697 0.79 NFKB1 (0.51) NFKB1NFKB2RELAJUNXPO1
SCHEMBL21746957 0.79 NFKB1 (0.55) NFKB1NFKB2RELAJUNXPO1
SCHEMBL429969 0.79 NFKB1 (0.46) NFKB1NFKB2RELAJUNXPO1
SCHEMBL31469871 0.79 NFKB1 (0.46) NFKB1NFKB2RELAJUNXPO1
SCHEMBL3435395 0.77 RAB9A (0.53) NFKB1NFKB2RELAJUNHPGD
SCHEMBL31391972 0.77 RAB9A (0.53) NFKB1NFKB2RELAJUNHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180133220-A1 COMPOUNDS FOR USE IN TREATING ACUTE CORONARY SYNDROME AND RELATED CONDITIONS VITAE PHARMACEUTICALS, LLC 2018-05-17 US disclosed
US-20180117041-A1 LIVER X RECEPTOR MODULATORS VITAE PHARMACEUTICALS, INC. 2018-05-03 US disclosed
US-20170231992-A1 COMPOUNDS FOR USE IN TREATING ACUTE CORONARY SYNDROME AND RELATED CONDITIONS VITAE PHARMACEUTICALS, INC. 2017-08-17 US disclosed
US-9707232-B2 Liver X receptor modulators VITAE PHARMACEUTICALS, INC. (US) 2017-07-18 US disclosed
US-20170007603-A1 LIVER X RECEPTOR MODULATORS VITAE PHARMACEUTICALS, LLC 2017-01-12 US disclosed
US-9416135-B2 Liver X receptor modulators VITAE PHARMACEUTICALS, INC. (US) 2016-08-16 US disclosed
US-20160113930-A1 COMPOUNDS FOR USE IN TREATING RETT SYNDROME VITAE PHARMACEUTICALS, INC. 2016-04-28 US disclosed
US-20150336963-A1 LIVER X RECEPTOR MODULATORS VITAE PHARMACEUTICALS, LLC 2015-11-26 US disclosed
US-20150250787-A1 COMPOUNDS FOR USE IN TREATING SKIN CANCERS VITAE PHARMACEUTICALS, INC. 2015-09-10 US disclosed
US-9073931-B2 Liver X receptor modulators VITAE PHARMACEUTICALS, INC. (US) 2015-07-07 US disclosed
US-4191686-A FROM SULFONYL HALIDE SUBSTITUTED PARENT BY AMIDATION WITH AROMATIC DIAMINE, DIAZOTIZING, COUPLING TO KETO SUCCINIC ESTER, CYCLIZING, COUPLING TO REACTIVE MOIETY CASSELLA AKTIENGESELLSCHAFT (DE) 1980-03-04 US disclosed
US-4126609-A AZO DYESTUFF WITH A FIBER-REACTIVE GROUP ATTACHED TO A NAPHTHALENE SULPHONIC ACID COMPONENT BAYER AKTIENGESELLSCHAFT (DE) 1978-11-21 US disclosed
US-4122079-A Reactive azo dyestuffs from diazotized sulfo-amino naphthalenes and diaminosulfobenzenes BAYER AKTIENGESELLSCHAFT (DE) 1978-10-24 US disclosed
US-4118382-A DYES FOR CELLULOSE, WOOL, SILK, POLYAMIDE, AND POLYURETHANE FIBERS BAYER AKTIENGESELLSCHAFT (DE) 1978-10-03 US disclosed
US-4089895-A COUPLER FOR AZO DYES BAYER AKTIENGESELLSCHAFT (DT) 1978-05-16 US disclosed
US-4065446-A Reactive dyestuffs containing urea alkylene linkage between chromophore and reactive radical BAYER AKTIENGESELLSCHAFT (DT) 1977-12-27 US disclosed
US-4049704-A AZO REACTIVE DYES BAYER AKTIENGESELLSCHAFT (DT) 1977-09-20 US disclosed
US-3989692-A PHTHALOCYANINE DYES, WOOL, SILK, POLYAMIDES, CELLULOSE BAYER AKTIENGESELLSCHAFT (DT) 1976-11-02 US disclosed
US-3988310-A FIBER-REACTIVE DYES; CELLULOSE BAYER AKTIENGESELLSCHAFT (DT) 1976-10-26 US disclosed
US-3957751-A WATER-SOLUBLE REACTIVE DYESTUFFS OF THE MONOAZO SERIES CONTAINING AN ACTIVE METHYLENE COUPLING COMPONENT HOECHST AKTIENGESELLSCHAFT (DT) 1976-05-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180117041-A1 LIVER X RECEPTOR MODULATORS SLC10A1, NR1H4, NR1H2 NFKB1 2853/4885NFKB2 2725/4885RELA 3119/4885
US-20150336963-A1 LIVER X RECEPTOR MODULATORS SLC10A1, NR1H4, NR1H2 NFKB1 2853/4885NFKB2 2725/4885RELA 3119/4885
US-20170231992-A1 COMPOUNDS FOR USE IN TREATING ACUTE CORONARY SYNDROME AND RELATED CONDITIONS TNNI3, FABP3, TNNT2 NFKB1 1156/4885NFKB2 1319/4885RELA 1668/4885
US-20160113930-A1 COMPOUNDS FOR USE IN TREATING RETT SYNDROME RET, RARS2, RARS1 NFKB1 4223/4885NFKB2 4188/4885RELA 4843/4885
US-20150250787-A1 COMPOUNDS FOR USE IN TREATING SKIN CANCERS TP53, KRT18, VHL NFKB1 1123/4885NFKB2 1359/4885RELA 1083/4885
US-20180133220-A1 COMPOUNDS FOR USE IN TREATING ACUTE CORONARY SYNDROME AND RELATED CONDITIONS TNNI3, FABP3, TNNT2 NFKB1 1156/4885NFKB2 1319/4885RELA 1668/4885
US-20170007603-A1 LIVER X RECEPTOR MODULATORS SLC10A1, NR1H4, NR1H2 NFKB1 2853/4885NFKB2 2725/4885RELA 3119/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.