Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 8/20 | 0.53 |
| ▸ | TP53 | P04637 | 4/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21747443 | 0.92 | HSD17B10 (0.58) | HSD17B10NPSR1MAPTTP53THRB | |
| SCHEMBL30468278 | 0.90 | HSD17B10 (0.53) | HSD17B10NPSR1MAPTTP53THRB | |
| SCHEMBL21747455 | 0.90 | SIRT1 (0.58) | HSD17B10NPSR1MAPTTP53THRB | |
| SCHEMBL21747469 | 0.89 | HSD17B10 (0.48) | HSD17B10NPSR1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL21747456 | 0.88 | HSD17B10 (0.54) | HSD17B10NPSR1MAPTTP53THRB | |
| SCHEMBL21747446 | 0.85 | TP53 (0.49) | HSD17B10NPSR1MAPTTP53HPGD | |
| SCHEMBL21747471 | 0.82 | HDAC1 (0.50) | HSD17B10NPSR1MAPTKDM4EALDH1A1 | |
| SCHEMBL30468309 | 0.81 | GPR119 (0.45) | HSD17B10MAPTHPGDKDM4EALDH1A1 | |
| SCHEMBL21747477 | 0.80 | SIRT1 (0.51) | HSD17B10TP53HPGDSMN1; SMN2KDM4E | |
| SCHEMBL21747493 | 0.79 | SIRT1 (0.51) | HSD17B10NPSR1MAPTHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613735-A1 | NOVEL SIRT 1 ACTIVATOR AND MEDICINAL USE THEREOF | Pusan National University Industry - University Cooperation Foundation (KR) | 2020-02-26 | — | — | EP | disclosed |