Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TYR | P14679 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL67741 | 0.97 | TSHR (0.55) | TSHRLMNATYRKIF11ALDH1A1 | |
| SCHEMBL6516058 | 0.94 | TSHR (0.52) | TSHRLMNATYRKIF11ALDH1A1 | |
| SCHEMBL6524730 | 0.94 | TSHR (0.52) | TSHRLMNATYRKIF11ALDH1A1 | |
| SCHEMBL2742259 | 0.89 | TSHR (0.48) | TSHRLMNATYRKIF11ALDH1A1 | |
| SCHEMBL16787954 | 0.89 | TSHR (0.48) | TSHRLMNATYRKIF11ALDH1A1 | |
| SCHEMBL14707718 | 0.89 | KIF11 (0.56) | TSHRLMNATYRKIF11ALDH1A1 | |
| SCHEMBL5478642 | 0.89 | KIF11 (0.56) | TSHRLMNATYRKIF11ALDH1A1 | |
| SCHEMBL11158002 | 0.85 | LMNA (0.48) | TSHRLMNATYRKIF11ALDH1A1 | |
| SCHEMBL23009776 | 0.83 | ADRA2A (0.44) | TSHRLMNATYRALDH1A1BCHE | |
| SCHEMBL18843945 | 0.83 | CYP1A2 (0.53) | TSHRLMNATYRALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088548-B2 | Bottom antireflective coating compositions | AZ ELECTRONIC MATERIALS USA CORP. (US) | 2012-01-03 | — | — | US | disclosed |
| EP-2212273-A2 | BOTTOM ANTIREFLECTIVE COATING COMPOSITIONS | AZ Electronic Materials USA Corp. (US) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009053832-A2 | BOTTOM ANTIREFLECTIVE COATING COMPOSITIONS | AZ ELECTRONIC MATERIALS USA CORP. (DE) | 2009-04-30 | — | — | WO | disclosed |
| US-20090104559-A1 | Bottom Antireflective Coating Compositions | MERCK PATENT GMBH (DE) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090104559-A1 | Bottom Antireflective Coating Compositions | SDC2, S100A9, MYH9 | ACHE 3212/4885TSHR 4603/4885LMNA 686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.