Sugi Predict

Sugi Predict / Compounds / SCHEMBL2174887

SCHEMBL2174887

SCHEMBL2174887

Cc1cccc(O[C@H]2C[C@H](C(=O)NO)[C@@](C)(C(=O)N3CCN(c4ccccc4)CC3)N(C(=O)O)C2)c1

nearest known ligand 0.40

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ EPHX2 P34913 1/20 0.40
▸ ADAM10 O14672 13/20 0.40
▸ MMP2 P08253 12/20 0.40
▸ ERBB2 P04626 12/20 0.40
▸ MMP9 P14780 7/20 0.40
▸ MMP3 P08254 6/20 0.40
▸ ALDH1A1 P00352 2/20 0.39
▸ LMNA P02545 2/20 0.39
▸ MAPT P10636 1/20 0.39
▸ MAPK1 P28482 1/20 0.39
▸ HTT P42858 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ MEN1 O00255 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ MGLL Q99685 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2174042 0.92 ADAM10 (0.44) ADAM10MMP2ERBB2MMP9MMP3
SCHEMBL2174462 0.92 ADAM10 (0.40) ADAM10MMP2ERBB2MMP9MMP3
SCHEMBL2174561 0.92 EPHX2 (0.40) EPHX2ADAM10MMP2ERBB2MMP9
SCHEMBL2172932 0.91 HRH3 (0.40) ADAM10MMP2ERBB2MMP9MMP3
SCHEMBL2172655 0.91 NR1H4 (0.41) EPHX2ADAM10MMP2ERBB2MMP9
SCHEMBL2173972 0.90 EPHX2 (0.42) EPHX2ADAM10MMP2ERBB2MMP9
SCHEMBL2173957 0.88 ADAM10 (0.41) ADAM10MMP2ERBB2MMP9MMP3
SCHEMBL2172738 0.88 ADAM10 (0.40) ADAM10MMP2ERBB2MMP9MMP3
SCHEMBL2172955 0.86 ADAM10 (0.41) EPHX2ADAM10MMP2ERBB2MMP9
SCHEMBL2172616 0.86 ADAM10 (0.41) ADAM10MMP2ERBB2MMP9MMP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110224189-A1 SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES INCYTE CORPORATION 2011-09-15 — — US claimed
US-20050113344-A1 Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases INCYTE CORPORATION 2005-05-26 — — US claimed
US-9440958-B2 Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases INCYTE CORPORATION (US) 2016-09-13 — — US disclosed
US-20110224189-A1 SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES INCYTE CORPORATION 2011-09-15 — — US disclosed
US-7973041-B2 Antiarthritic agents; psoriasis; anticancer agents;antiallergens; metalloprotease inhibitors. INCYTE CORPORATION (US) 2011-07-05 — — US disclosed
US-7491724-B2 Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases INCYTE CORPORATION (US) 2009-02-17 — — US disclosed
US-20050113344-A1 Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases INCYTE CORPORATION 2005-05-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110224189-A1 SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES MMP25, MMP14, MMP9 EPHX2 334/4885ADAM10 25/4885MMP2 4/4885
US-20050113344-A1 Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases MMP25, MMP2, MMP14 EPHX2 403/4885ADAM10 26/4885MMP2 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.