Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | PTPRB | P23467 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL21750113 | 0.81 | ALDH1A1 (0.55) | ALDH1A1TAAR1THRBATMMMP1 | |
| SCHEMBL22293355 | 0.80 | BCHE (0.53) | ALDH1A1THRBATMNPC1RAB9A | |
| SCHEMBL28313620 | 0.77 | ALDH1A1 (0.50) | ALDH1A1TAAR1THRBATMMMP1 | |
| SCHEMBL10807885 | 0.75 | HCAR2 (0.68) | ALDH1A1TAAR1THRBATMLDHA | |
| SCHEMBL8805999 | 0.75 | HCAR2 (0.68) | ALDH1A1TAAR1THRBATMLDHA | |
| SCHEMBL8806009 | 0.75 | HCAR2 (0.68) | ALDH1A1TAAR1THRBATMLDHA | |
| Maleic Acid SCHEMBL9416522 | 0.74 | HDAC3 (0.64) | ALDH1A1TAAR1THRBATMHDAC3 | |
| Fumaric Acid SCHEMBL9416528 | 0.74 | HDAC3 (0.64) | ALDH1A1TAAR1THRBATMHDAC3 | |
| Maleic Acid SCHEMBL8867414 | 0.74 | ALDH1A1 (0.48) | ALDH1A1TAAR1THRBATMMMP1 | |
| Fumaric Acid SCHEMBL8867443 | 0.74 | ALDH1A1 (0.48) | ALDH1A1TAAR1THRBATMMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558954-B1 | IMPROVED PROCESS FOR THE MANUFACTURE OF R-6-HYDROXY-8-[1-HYDROXY-2-[2-(4-METHOXYPHENYL)-1,1-DIMETHYLETHYLAMINOETHYL]-2H-1,4-BENZOXAZIN-3(4H)-ONE HYDROCHLORIDE | INKE SA (ES) | 2021-11-03 | — | — | EP | disclosed |
| US-10800748-B2 | Process for the manufacture of R-6-hydroxy-8-[1-hydroxy-2-[2-(4-methoxyphenyl)-1,1-dimethylethylaminoethyl]-2H-1,4-benzoxazin-3(4H)-one hydrochloride | INKE, S.A. (ES) | 2020-10-13 | — | — | US | disclosed |
| US-20200062723-A1 | IMPROVED PROCESS FOR THE MANUFACTURE OF R-6-HYDROXY-8-[1-HYDROXY-2-[2-(4-METHOXYPHENYL)-1,1-DIMETHYLETHYLAMINOETHYL]-2H-1,4-BENZOXAZIN-3(4H)-ONE HYDROCHLORIDE | LABORATORIOS LESVI, S.L. (ES) | 2020-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200062723-A1 | IMPROVED PROCESS FOR THE MANUFACTURE OF R-6-HYDROXY-8-[1-HYDROXY-2-[2-(4-METHOXYPHENYL)-1,1-DIMETHYLETHYLAMINOETHYL]-2H-1,4-BENZOXAZIN-3(4H)-ONE HYDROCHLORIDE | HTR6, HTR4, HAAO | ALDH1A1 401/4885TAAR1 180/4885CTSK 3420/4885 |
| US-10800748-B2 | Process for the manufacture of R-6-hydroxy-8-[1-hydroxy-2-[2-(4-methoxyphenyl)-1,1-dimethylethylaminoethyl]-2H-1,4-benzoxazin-3(4H)-one hydrochloride | HTR6, HTR4, SLC6A6 | ALDH1A1 304/4885TAAR1 186/4885CTSK 3538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.