Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.47 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.44 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.44 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.44 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.44 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | LDHA | P00338 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL28687879 | 0.90 | SLC6A2 (0.50) | ALDH1A1TAAR1LDHASLC6A2MMP1 | |
| SCHEMBL183751 | 0.86 | SLC6A2 (0.57) | ALDH1A1TAAR1SLC6A2SMN1; SMN2HTR2A | |
| Fumaric Acid SCHEMBL8867443 | 0.86 | ALDH1A1 (0.48) | ALDH1A1TAAR1THRBATMMMP1 | |
| Maleic Acid SCHEMBL8867414 | 0.86 | ALDH1A1 (0.48) | ALDH1A1TAAR1THRBATMMMP1 | |
| Cadaverine Tartrate SCHEMBL20298290 | 0.84 | LDHA (0.53) | TAAR1LDHASLC6A2MMP1MMP13 | |
| Tartaric Acid SCHEMBL30628113 | 0.84 | LDHA (0.53) | TAAR1LDHASLC6A2MMP1MMP13 | |
| Iodide SCHEMBL28694310 | 0.84 | SLC6A2 (0.55) | ALDH1A1TAAR1SLC6A2SMN1; SMN2HTR2A | |
| Hydrochloric Acid SCHEMBL3800374 | 0.84 | SLC6A2 (0.55) | ALDH1A1TAAR1SLC6A2HTR2ASLC6A4 | |
| Bromide SCHEMBL28700901 | 0.84 | SLC6A2 (0.55) | ALDH1A1TAAR1SLC6A2SMN1; SMN2HTR2A | |
| Sulfuric Acid SCHEMBL28679089 | 0.83 | PTPRB (0.49) | TAAR1LDHASLC6A2MMP1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110114346-B | Improved process for preparing R-6-hydroxy-8- [ 1-hydroxy-2- [2- (4-methoxyphenyl) -1, 1-dimethylethylaminoethyl ] -2H-1, 4-benzoxazin-3 (4H) -one hydrochloride | INKE股份公司 | 2023-10-31 | — | — | CN | disclosed |
| EP-3558954-B1 | IMPROVED PROCESS FOR THE MANUFACTURE OF R-6-HYDROXY-8-[1-HYDROXY-2-[2-(4-METHOXYPHENYL)-1,1-DIMETHYLETHYLAMINOETHYL]-2H-1,4-BENZOXAZIN-3(4H)-ONE HYDROCHLORIDE | INKE SA (ES) | 2021-11-03 | — | — | EP | disclosed |
| US-10800748-B2 | Process for the manufacture of R-6-hydroxy-8-[1-hydroxy-2-[2-(4-methoxyphenyl)-1,1-dimethylethylaminoethyl]-2H-1,4-benzoxazin-3(4H)-one hydrochloride | INKE, S.A. (ES) | 2020-10-13 | — | — | US | disclosed |
| US-20200062723-A1 | IMPROVED PROCESS FOR THE MANUFACTURE OF R-6-HYDROXY-8-[1-HYDROXY-2-[2-(4-METHOXYPHENYL)-1,1-DIMETHYLETHYLAMINOETHYL]-2H-1,4-BENZOXAZIN-3(4H)-ONE HYDROCHLORIDE | LABORATORIOS LESVI, S.L. (ES) | 2020-02-27 | — | — | US | disclosed |
| CN-110114346-A | Improved process for the preparation of R-6-hydroxy-8- [ 1-hydroxy-2- [2- (4-methoxyphenyl) -1, 1-dimethylethylaminoethyl ] -2H-1, 4-benzoxazin-3 (4H) -one hydrochloride | INKE股份公司 | 2019-08-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200062723-A1 | IMPROVED PROCESS FOR THE MANUFACTURE OF R-6-HYDROXY-8-[1-HYDROXY-2-[2-(4-METHOXYPHENYL)-1,1-DIMETHYLETHYLAMINOETHYL]-2H-1,4-BENZOXAZIN-3(4H)-ONE HYDROCHLORIDE | HTR6, HTR4, HAAO | SLC6A2 97/4885HTR2A 71/4885SLC6A4 19/4885 |
| US-10800748-B2 | Process for the manufacture of R-6-hydroxy-8-[1-hydroxy-2-[2-(4-methoxyphenyl)-1,1-dimethylethylaminoethyl]-2H-1,4-benzoxazin-3(4H)-one hydrochloride | HTR6, HTR4, SLC6A6 | SLC6A2 69/4885HTR2A 72/4885SLC6A4 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.