Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19206601 | 0.82 | TAAR1 (0.58) | TAAR1HTR3ATSHRNFKB1HIF1A | |
| SCHEMBL6274882 | 0.80 | RIPK1 (0.35) | TAAR1HTR3ATSHRNFKB1HIF1A | |
| SCHEMBL22399245 | 0.78 | LMNA (0.40) | TAAR1HIF1ATDP1KDM4ERIPK1 | |
| SCHEMBL317303 | 0.78 | LMNA (0.40) | TAAR1HIF1ATDP1KDM4ERIPK1 | |
| SCHEMBL29191773 | 0.78 | RIPK1 (0.34) | TAAR1HTR3ATSHRNFKB1HIF1A | |
| SCHEMBL16149774 | 0.77 | HRH1 (0.39) | HRH1 | |
| SCHEMBL3179795 | 0.77 | HRH1 (0.62) | TAAR1KDM4EHRH1RIPK1AOC3 | |
| SCHEMBL42066 | 0.77 | HRH1 (0.62) | TAAR1KDM4EHRH1RIPK1AOC3 | |
| SCHEMBL232834 | 0.77 | HRH1 (0.62) | TAAR1KDM4EHRH1RIPK1AOC3 | |
| SCHEMBL29191903 | 0.77 | PTGER2 (0.36) | RIPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103664637-A | Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders | ACUCELA INC | 2014-03-26 | — | — | CN | claimed |
| CN-101784188-B | Alkynyl phenyl derivative compounds for the treatment of ophthalmic diseases and disorders | ACUCELA INC | 2014-02-12 | — | — | CN | claimed |
| CN-101784188-A | Alkynyl phenyl derivative compounds for the treatment of ophthalmic diseases and disorders | ACUCELA INC | 2010-07-21 | — | — | CN | claimed |
| US-20220175700-A1 | VISUAL CYCLE MODULATORS | UNIV CASE WESTERN RESERVE (US) | 2022-06-09 | — | — | US | disclosed |
| US-11253489-B2 | Visual cycle modulators | CASE WESTERN RESERVE UNIVERSITY (US) | 2022-02-22 | — | — | US | disclosed |
| US-20200060996-A1 | VISUAL CYCLE MODULATORS | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERAN AFFAIRS | 2020-02-27 | — | — | US | disclosed |
| CN-105541769-A | Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders | ACUCELA INC | 2016-05-04 | — | — | CN | disclosed |
| CN-103664637-B | Be used for the treatment of ophthalmic diseases and disorderly alkynyl phenyl derivative compounds | ACUCELA INC. (US) | 2016-02-03 | — | — | CN | disclosed |
| CN-103664637-A | Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders | ACUCELA INC | 2014-03-26 | — | — | CN | disclosed |
| CN-101784188-B | Alkynyl phenyl derivative compounds for the treatment of ophthalmic diseases and disorders | ACUCELA INC | 2014-02-12 | — | — | CN | disclosed |
| CN-101917980-B | Amine derivative compounds for the treatment of ophthalmic diseases and disorders | ACUCELA INC | 2013-12-11 | — | — | CN | disclosed |
| CN-101917980-A | Amine derivative compounds for the treatment of ophthalmic diseases and disorders | ACUCELA INC | 2010-12-15 | — | — | CN | disclosed |
| CN-101784188-A | Alkynyl phenyl derivative compounds for the treatment of ophthalmic diseases and disorders | ACUCELA INC | 2010-07-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220175700-A1 | VISUAL CYCLE MODULATORS | ALDH1A2, UACA, NR2E3 | TAAR1 2039/4885HTR3A 1391/4885TSHR 909/4885 |
| US-20200060996-A1 | VISUAL CYCLE MODULATORS | ALDH1A2, UACA, NR2E3 | TAAR1 2039/4885HTR3A 1391/4885TSHR 909/4885 |
| US-11253489-B2 | Visual cycle modulators | ALDH1A2, UACA, NR2E3 | TAAR1 2039/4885HTR3A 1391/4885TSHR 909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.