Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 1/20 | 0.38 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 13/20 | 0.33 |
| ▸ | ACVR1B | P36896 | 8/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 7/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | LATS1 | O95835 | 1/20 | 0.33 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3379368 | 0.86 | AGER (0.36) | CCR4TGFBR1ACVR1BACVRL1PIM1 | |
| SCHEMBL3379888 | 0.82 | AGER (0.38) | CCR4TGFBR1ACVR1BACVRL1BMPR1A | |
| SCHEMBL3385997 | 0.81 | KDM4E (0.44) | CCR4ACP1TGFBR1ACVR1BACVRL1 | |
| SCHEMBL21756156 | 0.80 | TGFBR1 (0.39) | TGFBR1ACVR1BACVRL1PIM1FLT3 | |
| SCHEMBL3390023 | 0.80 | TGFBR1 (0.40) | ACP1TGFBR1ACVR1BACVRL1PIM1 | |
| SCHEMBL3381872 | 0.80 | HTR1A (0.38) | CCR4TGFBR1ACVR1BACVRL1CYP1A2 | |
| SCHEMBL3383241 | 0.80 | TGFBR1 (0.38) | TGFBR1ACVR1BACVRL1PIM1FLT3 | |
| SCHEMBL247224 | 0.79 | TBK1 (0.46) | ACP1TGFBR1ACVR1BACVRL1PIM1 | |
| SCHEMBL3379333 | 0.79 | IDO1 (0.39) | TGFBR1ACVR1BACVRL1PIM1FLT3 | |
| SCHEMBL12440185 | 0.77 | TGFBR1 (0.41) | ACP1TGFBR1ACVR1BACVRL1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585461-B1 | 2,4-DIARYL-SUBSTITUTED [1,8]NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER | MERCK PATENT GMBH (DE) | 2020-02-26 | — | — | EP | disclosed |