Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | CASP2 | P42575 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | RAD52 | P43351 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MDH1 | P40925 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21753150 | 0.93 | MEN1 (0.47) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL21756907 | 0.86 | MEN1 (0.39) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL21756960 | 0.78 | MEN1 (0.44) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL27845478 | 0.77 | LMNA (0.61) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL21756912 | 0.69 | MEN1 (0.38) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL15055320 | 0.69 | ALDH1A1 (0.79) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL19638852 | 0.69 | ALDH1A1 (0.79) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL21752967 | 0.69 | LMNA (0.52) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL16216731 | 0.69 | LMNA (0.52) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL27210045 | 0.69 | MEN1 (0.52) | MEN1KMT2ARAB9ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020039092-A2 | NOVEL AROMATIC MOLECULES | Xeniopro GmbH (DE) | 2020-02-27 | — | — | WO | disclosed |
| US-9403829-B2 | Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1H)-one, a solid form thereof and methods of their use | SIGNAL PHARMACEUTICALS, LLC (US) | 2016-08-02 | — | — | US | disclosed |